Low-level prenatal lead exposure and neurobehavioral development of children in the first year of life: A prospective study in Shanghai

Journal Article · Thu Oct 01 04:00:00 EDT 1998 · Environmental Research

DOI:https://doi.org/10.1006/enrs.1998.3851· OSTI ID:653164

Shen, X M; Yan, C H; Guo, D ^[1]

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1. Shanghai Second Medical Univ. (China). Research Center for Childhood Lead Poisoning Prevention; and others

The authors used a prospective study design to assess the effects of prenatal low-level lead exposure on the development of urban, inner-city children in Shanghai. Umbilical cord blood samples were consecutively collected from 605 live newborns. Two hundred and fifty-seven samples were excluded from the study due to clotting. Lead levels were determined on 348 cord blood samples. The geometric mean was 9.2 {micro}g/dl. Based on their cord blood lead levels, infants were classified into two exposure groups: 104 in a relatively low lead group (lead levels {le} 30%), and 104 in a relatively high lead group (lead levels {ge} 70%). Seventy-five subjects failed to complete the study, and 133 babies were included in the final cohort: 69 babies in the high lead group and 64 in the low lead group. At 3, 6, and 12 months, the Bayley Scales of Infant Development were administered and capillary blood lead levels were measured. Detailed information was obtained on a wide range of variables relevant to infant development. At all three ages, the Mental Development Index (MDI) scores, adjusted for confounders, were inversely related to the infants` cord blood lead levels.

• OSTI ID: 653164
• Journal Information: Environmental Research, Journal Name: Environmental Research Journal Issue: 1 Vol. 79; ISSN ENVRAL; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
AIR POLLUTION
BIOLOGICAL ACCUMULATION
CHILDREN
CHINA
EPIDEMIOLOGY
NERVOUS SYSTEM DISEASES
PRENATAL EXPOSURE