Lead exposure and neurobehavior development in later infancy

Journal Article · Thu Nov 01 04:00:00 EST 1990 · Environmental Health Perspectives; (USA)

DOI:https://doi.org/10.1289/ehp.908913· OSTI ID:5840137

Dietrich, K N; Succop, P A; Bornschein, R L; Hammond, P B; Buncher, C R; Berger, O ^[1]; Krafft, K M ^[2]

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1. Univ. of Cincinnati College of Medicine, OH (USA)
2. E.I. du Pont de Nemours Inc., Wilmington, DE (USA)

A prospective methodology was used to assess the neurobehavioral effects of fetal and postnatal lead exposure during the first 2 years of life. Lead was measured in whole blood prenatally in mothers and at quarterly intervals in the infant. Prenatal blood lead levels were low (mean = 8.0 {mu}g/dL). However, approximately 25% of the study infants had at least one serial blood lead level of 25 {mu}g/dL or higher during the second year of life. Multiple regression and structural equation analyses revealed statistically significant relationships between prenatal and neonatal blood lead level and 3- and 6-month Bayley Mental and/or Psychomotor Development Index. However, by 2 years of age, no statistically significant effects of prenatal or postnatal lead exposure on neurobehavioral development could be detected. Data consistent with the hypothesis that a postnatal neurobehavioral growth catch-up occurred in infants exposed fetally to higher levels of lead are presented.

• OSTI ID: 5840137
• Journal Information: Environmental Health Perspectives; (USA), Journal Name: Environmental Health Perspectives; (USA) Vol. 89; ISSN 0091-6765; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
BEHAVIOR
BIOLOGICAL EFFECTS
BLOOD CHEMISTRY
CHILDREN
INFANTS
LEAD COMPOUNDS
MATHEMATICS
ONTOGENESIS
PRENATAL EXPOSURE
REGRESSION ANALYSIS
RESEARCH PROGRAMS
STATISTICS