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Title: Cerebrospinal fluid flow abnormalities in patients with neoplastic meningitis. An evaluation using /sup 111/In-DTPA ventriculography

Abstract

Cerebrospinal fluid flow dynamics were evaluated by /sup 111/In-diethylenetriamine pentaacetic acid (/sup 111/In-DTPA) ventriculography in 27 patients with neoplastic meningitis. Nineteen patients (70 percent) had evidence of cerebrospinal fluid flow disturbances. These occurred as ventricular outlet obstructions, abnormalities of flow in the spinal canal, or flow distrubances over the cortical convexities. Tumor histology, physical examination, cerebrospinal fluid analysis, myelograms, and computerized axial tomographic scans were not sufficient to predict cerebrospinal fluid flow patterns. These data indicate that cerebrospinal fluid flow abnormalities are common in patients with neoplastic meningitis and that /sup 111/In-DTPA cerebrospinal fluid flow imaging is useful in characterizing these abnormalities. This technique provides insight into the distribution of intraventricularly administered chemotherapy and may provide explanations for treatment failure and drug-induced neurotoxicity in patients with neoplastic meningitis.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Johns Hopkins Oncology Center, Baltimore, Maryland
OSTI Identifier:
6531538
Alternate Identifier(s):
OSTI ID: 6531538
Resource Type:
Journal Article
Resource Relation:
Journal Name: Am. J. Med.; (United States); Journal Volume: 73:5
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; INDIUM 111; DIAGNOSTIC USES; NEOPLASMS; DIAGNOSIS; NERVOUS SYSTEM DISEASES; CEREBROSPINAL FLUID; DTPA; FLUID FLOW; LABELLED COMPOUNDS; MENINGES; PATIENTS; AMINO ACIDS; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BODY FLUIDS; CARBOXYLIC ACIDS; CHELATING AGENTS; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MATERIALS; MEMBRANES; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; USES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics; 551001 -- Physiological Systems-- Tracer Techniques; 550901 -- Pathology-- Tracer Techniques

Citation Formats

Grossman, S.A., Trump, D.L., Chen, D.C., Thompson, G., and Camargo, E.E.. Cerebrospinal fluid flow abnormalities in patients with neoplastic meningitis. An evaluation using /sup 111/In-DTPA ventriculography. United States: N. p., 1982. Web.
Grossman, S.A., Trump, D.L., Chen, D.C., Thompson, G., & Camargo, E.E.. Cerebrospinal fluid flow abnormalities in patients with neoplastic meningitis. An evaluation using /sup 111/In-DTPA ventriculography. United States.
Grossman, S.A., Trump, D.L., Chen, D.C., Thompson, G., and Camargo, E.E.. Mon . "Cerebrospinal fluid flow abnormalities in patients with neoplastic meningitis. An evaluation using /sup 111/In-DTPA ventriculography". United States.
@article{osti_6531538,
title = {Cerebrospinal fluid flow abnormalities in patients with neoplastic meningitis. An evaluation using /sup 111/In-DTPA ventriculography},
author = {Grossman, S.A. and Trump, D.L. and Chen, D.C. and Thompson, G. and Camargo, E.E.},
abstractNote = {Cerebrospinal fluid flow dynamics were evaluated by /sup 111/In-diethylenetriamine pentaacetic acid (/sup 111/In-DTPA) ventriculography in 27 patients with neoplastic meningitis. Nineteen patients (70 percent) had evidence of cerebrospinal fluid flow disturbances. These occurred as ventricular outlet obstructions, abnormalities of flow in the spinal canal, or flow distrubances over the cortical convexities. Tumor histology, physical examination, cerebrospinal fluid analysis, myelograms, and computerized axial tomographic scans were not sufficient to predict cerebrospinal fluid flow patterns. These data indicate that cerebrospinal fluid flow abnormalities are common in patients with neoplastic meningitis and that /sup 111/In-DTPA cerebrospinal fluid flow imaging is useful in characterizing these abnormalities. This technique provides insight into the distribution of intraventricularly administered chemotherapy and may provide explanations for treatment failure and drug-induced neurotoxicity in patients with neoplastic meningitis.},
doi = {},
journal = {Am. J. Med.; (United States)},
number = ,
volume = 73:5,
place = {United States},
year = {Mon Nov 01 00:00:00 EST 1982},
month = {Mon Nov 01 00:00:00 EST 1982}
}