Identification of a fibronectin receptor specific for rat liver endothelial cells
Journal Article
·
· Experimental Cell Research; (USA)
- Univ. of Uppsala (Sweden)
Antibodies raised against the fibronectin receptor of rat hepatocytes recognized one protein in immunoblotting of solubilized rat liver endothelial cells (LEC). The antibodies specifically precipitated a 200-kDa protein together with the 135-kDa component from {sup 125}I-labeled LEC. Spreading of LEC on fibronectin, but not on laminin or collagen, was inhibited by monovalent Fab fragments of the antibodies, implicating that the 135/200-kDa complex is a specific fibronectin receptor. The results indicate that LEC, hepatocytes, and fibroblasts of rat carry different fibronectin receptors, suggesting that the interaction of fibronectin with these cells may have different functional roles.
- OSTI ID:
- 6530858
- Journal Information:
- Experimental Cell Research; (USA), Journal Name: Experimental Cell Research; (USA) Vol. 172:2; ISSN ECREA; ISSN 0014-4827
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550301* -- Cytology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANIMALS
ANTIGENS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BODY
COAGULANTS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ELECTROPHORESIS
ENDOTHELIUM
FIBRIN
GLANDS
HEMATOLOGIC AGENTS
HEMOSTATICS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
LABELLING
LIVER
MAMMALS
MEMBRANE PROTEINS
MOLECULAR STRUCTURE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
RATS
RECEPTORS
RODENTS
SCLEROPROTEINS
TISSUES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANIMALS
ANTIGENS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BODY
COAGULANTS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ELECTROPHORESIS
ENDOTHELIUM
FIBRIN
GLANDS
HEMATOLOGIC AGENTS
HEMOSTATICS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
LABELLING
LIVER
MAMMALS
MEMBRANE PROTEINS
MOLECULAR STRUCTURE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
RATS
RECEPTORS
RODENTS
SCLEROPROTEINS
TISSUES
VERTEBRATES