Studies on the radioprotective effects of superoxide dismutase in mice
Protective effects of superoxide dismutase (SOD) on radiation-induced skin reactions of mice were examined as a function of the drug concentration and the modes of its administration. The anti-inflammatory effects of SOD was most prominent when 1 mg/mouse of SOD was given i.p. one hour before and one hour after irradiation, followed by 0.5 mg/mouse daily. Protective effects of SOD as a function of radiation dose were examined using deforming scores for the mouse leg as a measure of response. Protective effects of the drug was observed in the range of 40 to 70 Gy, while no effect was obtained in the dose level less than 40 Gy. The dose required to kill 50% of the SOD treated mice within 30 days (LD/sub 50/30/) was 7.84 Gy as compared to 7.54 Gy for the control group of mice.
- Research Organization:
- Kyoto Univ., Japan
- OSTI ID:
- 6527827
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:2; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DATA
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
ENZYMES
EXPERIMENTAL DATA
GAMMA RADIATION
INFORMATION
IONIZING RADIATIONS
LETHAL DOSES
LETHAL RADIATION DOSE
MAMMALS
MICE
NUMERICAL DATA
ORGANS
OXIDOREDUCTASES
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADICALS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RODENTS
SKIN
SUPEROXIDE RADICALS
TIME DEPENDENCE
VERTEBRATES