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Genotoxic effects of sunlight-activated waste waters

Conference ·
OSTI ID:6527409
; ;
Natural sunlight induces a genotoxic response in cultured CHO cells pre-treated with shale oil retort process water. Near ultraviolet light (NUV) component of the solar spectrum is the apparent radiation responsible for photoactivation. Cultured human skin fibroblasts are acutely sensitive to the genotoxic effects of photoactivated process water. The mutagenic potential of photoactivated process water in human cells is the same as that witnessed for an equivalent killing dose of the potent skin carcinogen FUV. DNA repair processes are involved in modulating genotoxic effects of this photo-induced process. The exact magnitude of the potential health-related and environmental risks resulting from photoactivation of retort process waters and other oil shale by-products is unassessed at this time. Our demonstration that a significant rate of mutation occurs in cultured human cells exposed to high dilutions of process waters and fluences of NUV comparable to that encountered during nominal exposure to sunlight suggests that such assessment is a prerequisite to minimal risk development of our oil shale resources.
Research Organization:
Los Alamos National Lab., NM (USA)
DOE Contract Number:
W-7405-ENG-36
OSTI ID:
6527409
Report Number(s):
LA-UR-81-986; CONF-810357-1
Country of Publication:
United States
Language:
English

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Related Subjects

04 OIL SHALES AND TAR SANDS
040700 -- Oil Shales & Tar Sands-- Health & Safety
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BITUMINOUS MATERIALS
BODY
CARBONACEOUS MATERIALS
CELL CULTURES
CHEMICAL REACTIONS
CONNECTIVE TISSUE CELLS
DECOMPOSITION
DNA
ELECTROMAGNETIC RADIATION
ENERGY SOURCES
ENVIRONMENTAL IMPACTS
EPITHELIUM
FIBROBLASTS
FOSSIL FUELS
FUELS
GENETIC EFFECTS
HAZARDS
HEALTH HAZARDS
HYDROGEN COMPOUNDS
LIQUID WASTES
MATERIALS
MUTAGENESIS
NEAR ULTRAVIOLET RADIATION
NUCLEIC ACIDS
OIL SHALES
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
PHOTOCHEMICAL REACTIONS
PHOTOREACTIVATION
RADIATIONS
RECOVERY
REPAIR
RETORTING
SOMATIC CELLS
SYNERGISM
TISSUES
TOXICITY
ULTRAVIOLET RADIATION
WASTE WATER
WASTES
WATER