Effects of partial replacement of dietary fat by olestra on dietary cholesterol absorption in man

Journal Article · Wed Aug 01 04:00:00 EDT 1990 · Metabolism, Clinical and Experimental; (USA)

DOI:https://doi.org/10.1016/0026-0495(90)90131-U· OSTI ID:6527349

Jandacek, R J; Ramirez, M M; Crouse, III, J R ^[1]

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1. Procter Gamble Company, Cincinnati, OH (USA)

Olestra, a nonabsorbable fat substitute comprising long-chain fatty acid esters of sucrose, had been previously shown to reduce cholesterol absorption in humans when ingested at a level of 50 g/d. To determine whether or not a lower level of dietary olestra would also reduce cholesterol absorption, we studied the effect of 7 g of olestra twice a day in 20 normocholesterolemic male inpatients in a double-blind, crossover trial. Two 6-day diet treatment and stool collection periods were separated by a 14-day washout period. Half of the subjects received butter, and half, a butter-olestra blend during each treatment period according to a crossover design. All subjects ingested trace amounts of 3H-cholesterol and 14C-beta-sitosterol with the butter or the butter-olestra blend. Cholesterol absorption was determined from the 3H/14C ratios in the diet and in saponified and extracted stools according to previously validated methodology. Cholesterol absorption during the butter regimen was significantly greater than that during the olestra regimen (56.1% +/- 1.6% v 46.7% +/- 1.1%, P less than .01).

• OSTI ID: 6527349
• Journal Information: Metabolism, Clinical and Experimental; (USA), Journal Name: Metabolism, Clinical and Experimental; (USA) Vol. 39:8; ISSN METAA; ISSN 0026-0495
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
ANIMALS
CARBOHYDRATES
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CHOLESTEROL
DIET
DISACCHARIDES
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
INTESTINAL ABSORPTION
ISOTOPE APPLICATIONS
ISOTOPE DILUTION
ISOTOPE RATIO
LABELLED COMPOUNDS
MAMMALS
MAN
METABOLISM
OLIGOSACCHARIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
PRIMATES
SACCHARIDES
SACCHAROSE
STEROIDS
STEROLS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES