Distribution and kinetics of glucose in rats analyzed by noncompartmental and compartmental analysis
Journal Article
·
· American Journal of Physiology; (USA)
OSTI ID:6527252
- Univ. of Ottawa, Ontario (Canada)
The steady-state kinetics and distribution of glucose were assessed using noncompartmental and various two-compartment models in rats that were infused with insulin (+/- euglycemic clamping), methylprednisolone (MP), or phlorizin (PHL) as well as rats injected with protamine-zinc-insulin (PZI) or rendered diabetic. Decreases in clearance of glucose (PCR) were greatest with insulin infusion, followed by PHL, MP, and PZI treatments. PCR decreased in diabetes to 25% of normal. With hyperinsulinemia and euglycemia, turnover rates were 1.18 times the rate of glucose infusion. In normal rats the ratio of the contents of the two compartments was 0.6-0.8 (depending on the model). Significant increases, of between 2.8 and 5.2, were observed with insulin infusion and between 0.8 and 1.8 with PHL, again depending on the model. Because PHL-induced changes in PCR are renal, these data suggest that variations in glucose distribution depend on changes in PCR as well as insulin. The intercompartmental rate constant decreased, and the noncompartmental volume of distribution increased to reflect the above changes. In non-steady-state studies, glucose release increased in response to insulin but not to PHL in contrast to other species.
- OSTI ID:
- 6527252
- Journal Information:
- American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 259:2 Pt 1; ISSN 0002-9513; ISSN AJPHA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501* -- Metabolism-- Tracer Techniques
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMALS
BIOCHEMICAL REACTION KINETICS
CARBOHYDRATES
CARBON ISOTOPES
CLEARANCE
DIABETES MELLITUS
DISEASES
DISTRIBUTION
ENDOCRINE DISEASES
GLUCOSE
HEXOSES
HORMONES
HYDROGEN COMPOUNDS
INSULIN
ISOTOPE APPLICATIONS
ISOTOPE DILUTION
ISOTOPES
KINETICS
MAMMALS
METABOLIC DISEASES
METABOLISM
MONOSACCHARIDES
ORGANIC COMPOUNDS
PATHOGENESIS
PEPTIDE HORMONES
RATS
REACTION KINETICS
RODENTS
SACCHARIDES
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMALS
BIOCHEMICAL REACTION KINETICS
CARBOHYDRATES
CARBON ISOTOPES
CLEARANCE
DIABETES MELLITUS
DISEASES
DISTRIBUTION
ENDOCRINE DISEASES
GLUCOSE
HEXOSES
HORMONES
HYDROGEN COMPOUNDS
INSULIN
ISOTOPE APPLICATIONS
ISOTOPE DILUTION
ISOTOPES
KINETICS
MAMMALS
METABOLIC DISEASES
METABOLISM
MONOSACCHARIDES
ORGANIC COMPOUNDS
PATHOGENESIS
PEPTIDE HORMONES
RATS
REACTION KINETICS
RODENTS
SACCHARIDES
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES