Structural inhibition and reactivation of Escherichia coli septation by elements of the SOS and TER pathways

Journal Article · Wed Apr 01 04:00:00 EST 1987 · J. Bacteriol.; (United States)

OSTI ID:6526360

Dopazo, A; Tormo, A; Aldea, M; Vicente, M

The inhibition of cell division caused by induction of the SOS pathway in Escherichia coli structurally blocks septation, as deduced from two sets of results. Potential septation sites active at the time of SOS induction became inactivated, while those initiated during the following doubling time were active. Penicillin resistance increased in wild-type UV light-irradiated cells, a behavior similar to that observed in mutants in which structural blocks were introduced by inactivation of FtsA. Potential septation sites that have been structurally blocked by either the SOS division inhibitor, furazlocillin inhibition of PBP3, or inactivation of a TER pathway component, FtsA3, could be reactivated one doubling time after removal of the inhibitory agent in the presence of an active lon gene product. Reactivation of potential septation sites blocked by the presence of an inactivated FtsA3 was significantly lower when the lon protease was not active, suggesting that Lon plays a role in the removal of inactivated TER pathway products from the blocked potential septation sites.

• Research Organization: Consejo Superior de Investigaciones Cientificas, Madrid, Spain
• OSTI ID: 6526360
• Journal Information: J. Bacteriol.; (United States), Journal Name: J. Bacteriol.; (United States) Vol. 4; ISSN JOBAA
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
560130 -- Radiation Effects on Microorganisms
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL CYCLE
CELL DIVISION
DNA REPAIR
DRUGS
ELECTROMAGNETIC RADIATION
ESCHERICHIA COLI
GENES
INHIBITION
MICROORGANISMS
PENICILLIN
RADIATION EFFECTS
RADIATIONS
RECOVERY
REGENERATION
REPAIR
TOLERANCE
ULTRAVIOLET RADIATION