125-iodine reimplantation for locally progressive prostatic carcinoma

Journal Article · Sat Sep 01 04:00:00 EDT 1990 · Journal of Urology; (USA)

OSTI ID:6526160

Wallner, K E; Nori, D; Morse, M J; Sogani, P C; Whitmore, W F; Fuks, Z ^[1]

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1. Memorial Sloan-Kettering Cancer Center, New York, NY (USA)

We treated 13 patients with a second 125-iodine implant for local recurrence of prostatic carcinoma. All patients had biopsy proved palpable recurrence without evidence of distant metastases. Full doses of irradiation were used (median matched peripheral dose 170 Gy.). Six patients had complete regression of palpable recurrence, 2 had partial regression, 2 had no apparent response and 3 were unevaluable for local response. Actuarial freedom from local disease progression at 5 years was 51%. Despite a relatively high rate of local disease control the actuarial rate of distant metastases reached 100% at 6 years after reimplantation. There were 2 severe rectal complications and 4 instances of mild to moderate urinary incontinence among the 13 patients. Local regression of recurrent prostatic carcinoma may be achieved with 125-iodine reimplantation but most patients still had distant metastases.

• OSTI ID: 6526160
• Journal Information: Journal of Urology; (USA), Journal Name: Journal of Urology; (USA) Vol. 144:3; ISSN JOURA; ISSN 0022-5347
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BODY
CARCINOMAS
DAYS LIVING RADIOISOTOPES
DISEASES
DOSES
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
IMPLANTS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
MALE GENITALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
PROSTATE
RADIATION DOSES
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
THERAPY