Iodine-125 prostate implants for recurrent carcinomas after external beam irradiation: preliminary results

Conference · Sun Jun 01 04:00:00 EDT 1980 · Cancer; (United States)

OSTI ID:5220244

Goffinet, D R; Martinez, A; Freiha, F; Pooler, D M; Pistenma, D A; Cumes, D; Bagshaw, M A

Fourteen patients with locally recurrent prostate carcinomas after external beam irradiation received /sup 125/I seed implants at Stanford between 1975 and 1979. Clinical local control was obtained in 11 of the 14 patients for follow-up periods of 6 to 36 months. Eight remain without evidence of disease, but 2 of the 3 patients whose pelvic lymph nodes were involved by carcinoma have developed distant metastases. Complications, consisting of either cystoproctitis, urinary incontinence, or the development of a vesicorectal fistula occurred in 4 of the 14 patients. These complications were noted only in those patients who had implantation of high intensity /sup 125/I seeds (>0.50 mCi) into large prostatic volumes (greater than or equal to 50cc). No complications occurred in patients who received lower intensity /sup 125/I seed implants in smaller prostatic volumes. We conclude that /sup 125/I seed implants may be used in a second attempt to obtain local control after a local relapse following external beam irradiation, if the use of high intensity /sup 125/I sources and/or the implantation of large prostate volumes are avoided.

• Research Organization: Stanford Univ., CA
• OSTI ID: 5220244
• Conference Information: Journal Name: Cancer; (United States) Journal Volume: 45:11
• Country of Publication: United States
• Language: English

Related Subjects

550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLADDER
BODY
BODY AREAS
CARCINOMAS
DAYS LIVING RADIOISOTOPES
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTRON CAPTURE RADIOISOTOPES
FISTULAE
GASTROINTESTINAL TRACT
GLANDS
IMPLANTS
INFLAMMATION
INTERMEDIATE MASS NUCLEI
INTESTINES
IODINE 125
IODINE ISOTOPES
IRRADIATION
ISOTOPES
LARGE INTESTINE
LOCAL IRRADIATION
MALE GENITALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PELVIS
PROSTATE
RADIATION EFFECTS
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RECTUM
SIDE EFFECTS
THERAPY
URINARY TRACT
UROGENITAL SYSTEM DISEASES