Unusual thyroid scintigrams in Plummer's disease during methimazole therapy. Conversion of hot to hypofunctional nodules

Journal Article · Sun Jul 01 00:00:00 EDT 1990 · Clinical Nuclear Medicine; (USA)

DOI:https://doi.org/10.1097/00003072-199007000-00002· OSTI ID:6525873

Tamai, H; Nagai, K; Ishimoto, J; Matsubayashi, S; Matsuzuka, F; Miyauchi, A; Kuma, K; Nagataki, S ^[1]

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1. Kyushu Univ., Fukuoka (Japan)

Thyroid scintigrams of two women (aged 48 and 58) with Plummer's disease showed unusual radioiodine accumulation during treatment with methimazole (MMI). Before MMI therapy, the scintigrams revealed most of the radioiodine uptake only in the nodules of the patients and very little uptake in the non-nodular portions of the thyroid. After initiation of MMI therapy, scintigrams performed at three and eight months revealed that the hot nodules had become hypofunctional and that the surrounding tissues had normal radioiodine accumulation. The findings indicate that the nodules in Plummer's disease continue to concentrate MMI selectively compared with normal surrounding thyroid tissue during therapy.

• OSTI ID: 6525873
• Journal Information: Clinical Nuclear Medicine; (USA), Journal Name: Clinical Nuclear Medicine; (USA) Vol. 15:7; ISSN CNMED; ISSN 0363-9762
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
ENDOCRINE GLANDS
ESOPHAGUS
GLANDS
IODINE ISOTOPES
ISOTOPES
NEOPLASMS
ORGANS
PATIENTS
RADIOISOTOPE SCANNING
SCINTISCANNING
THYROID