Limitations to benzene cancer risk assessment by Cox and Ricci
Journal Article
·
· Risk Analysis; (United States)
- Clement International Corp., Ruston, LA (United States)
Cox and Ricci estimated human cancer risks from exposure to benzene by applying the linearized multi-stage model (LMS) to data on tumor responses in male mice. The unique feature of their analysis was their use of internal measures of dose estimated using a physiologically based pharmokinetic (PBPK) model. It is the authors' opinion that the inclusion of all squamous cell carcinomas in the Cox and Ricci experiment was not the most appropriate animal tumor category for the analysis. In addition, the authors' feel that to develop a dose-response curve for humans, it is reasonable to model a tumor that is more closely related to the observed human cancer endpoint, which is leukemia. To determine how robust the risk estimates made by Cox and Ricci were to different animal endpoints, in this work their methods were applied to two additional endpoints in mice: malignant lymphoma and alveolar/bronchial carcinoma. The methodology produced a good statistical fit to both sets of data.
- OSTI ID:
- 6525811
- Journal Information:
- Risk Analysis; (United States), Journal Name: Risk Analysis; (United States) Vol. 13:2; ISSN 0272-4332; ISSN RIANDF
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550900* -- Pathology
560300 -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZENE
CARCINOMAS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EXTRAPOLATION
HAZARDS
HEALTH HAZARDS
HUMAN POPULATIONS
HYDROCARBONS
IMMUNE SYSTEM DISEASES
LEUKEMIA
MAMMALS
MATHEMATICS
MICE
NEOPLASMS
NUMERICAL SOLUTION
ORGANIC COMPOUNDS
POPULATIONS
PUBLIC HEALTH
RISK ASSESSMENT
RODENTS
STATISTICS
TESTING
VALIDATION
VERTEBRATES
560300 -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZENE
CARCINOMAS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EXTRAPOLATION
HAZARDS
HEALTH HAZARDS
HUMAN POPULATIONS
HYDROCARBONS
IMMUNE SYSTEM DISEASES
LEUKEMIA
MAMMALS
MATHEMATICS
MICE
NEOPLASMS
NUMERICAL SOLUTION
ORGANIC COMPOUNDS
POPULATIONS
PUBLIC HEALTH
RISK ASSESSMENT
RODENTS
STATISTICS
TESTING
VALIDATION
VERTEBRATES