Dangerous and cancer-causing properties of products and chemicals in the oil refining and petrochemical industry--Part II: Carcinogenicity, mutagenicity, and developmental toxicity of 1,3-butadiene

Journal Article · Wed May 01 04:00:00 EDT 1991 · Toxicology and Industrial Health; (United States)

DOI:https://doi.org/10.1177/074823379100700306· OSTI ID:5980844

Mehlman, M A; Legator, M S ^[1]

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1. UMDNJ-Robert Wood Johnson Medical School, Department of Environmental and Community Medicine, Piscataway, NJ (United States)

1,3-butadiene (BD) is present in synthetic rubber and motor fuels (gasoline). BD is shown to cause lymphocytic lymphomas, heart hemangiosarcomas, lung alveolar bronchiolar cancers, forestomach-squamous cell cancers, harderian gland neoplasms, preputial gland adenoma or carcinoma, liver-hepatocellular cancers, mammary gland acinar cell carcinomas, ovary-glanulosa cell carcinoma, brain cancers, pancreas adenoma and carcinoma, testis-Leydig cell tumors, thyroid follicular adenoma and carcinoma, and zymbal gland carcinoma in rodents and to date no exposure level has been established at which this chemical does not cause cancers. In humans BD causes increase in lymphomas, leukemias, and other cancers of hematopoietic systems and organs. BD is also a potent alkylating agent, directly toxic to developing embryos and damages progeny after parental exposure.29 references.

• OSTI ID: 5980844
• Journal Information: Toxicology and Industrial Health; (United States), Journal Name: Toxicology and Industrial Health; (United States) Vol. 7:3; ISSN TIHEE; ISSN 0748-2337
• Country of Publication: United States
• Language: English

Related Subjects

02 PETROLEUM
020600* -- Petroleum-- Health & Safety
ANIMALS
BUTADIENE
CARCINOGENESIS
DIENES
ENERGY SOURCES
FOSSIL FUELS
FUELS
HAZARDS
HEALTH HAZARDS
HYDROCARBONS
INDUSTRY
MAMMALS
MAN
MUTAGENESIS
ORGANIC COMPOUNDS
PATHOGENESIS
PETROLEUM
PETROLEUM INDUSTRY
POLYENES
PRIMATES
TERATOGENESIS
TOXICITY
VERTEBRATES