Effect of anxiety on cortical cerebral blood flow and metabolism

Journal Article · Wed Apr 01 04:00:00 EST 1987 · J. Cereb. Blood Flow Metab.; (United States)

DOI:https://doi.org/10.1038/jcbfm.1987.40· OSTI ID:6525069

Gur, R C; Gur, R E; Resnick, S M; Skolnick, B E; Alavi, A; Reivich, M

The relation between anxiety and cortical activity was compared in two samples of normal volunteers. One group was studied with the noninvasive xenon-133 inhalation technique for measuring cerebral blood flow (CBF) and the other with positron emission tomography (PET) using /sup 18/Flurodeoxyglucose (/sup 18/FDG) for measuring cerebral metabolic rates (CMR) for glucose. The inhalation technique produced less anxiety than the PET procedure, and for low anxiety subjects, there was a linear increase in CBF with anxiety. For higher anxiety subjects, however, there was a linear decrease in CBF with increased anxiety. The PET group manifested a linear decrease in CMR with increased anxiety. The results indicate that anxiety can have systematic effects on cortical activity, and this should be taken into consideration when comparing data from different procedures. They also suggest a physiologic explanation of a fundamental behavioral law that stipulates a curvilinear, inverted-U relationship between anxiety and performance.

• Research Organization: Univ. of Pennsylvania, Philadelphia
• OSTI ID: 6525069
• Journal Information: J. Cereb. Blood Flow Metab.; (United States), Journal Name: J. Cereb. Blood Flow Metab.; (United States) Vol. 2; ISSN JCBMD
• Country of Publication: United States
• Language: English

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BETA DECAY RADIOISOTOPES
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BETA-PLUS DECAY RADIOISOTOPES
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INHALATION
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MATHEMATICS
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