Effects of epidermal growth factor on neural crest cells in tissue culture

Journal Article · Wed Apr 01 00:00:00 EST 1987 · Exp. Cell Res.; (United States)

DOI:https://doi.org/10.1016/0014-4827(87)90189-3· OSTI ID:6524195

Erickson, C A; Turley, E A

Epidermal growth factor (EGF) stimulates the release of hyaluronic acid (HA) and chondroitin sulfate proteoglycan (CSPG) from quail trunk neural crest cultures in a dose-dependent fashion. It also promotes the expression of cell-associated heparan sulfate proteoglycan (HSPG) as detected by immunofluorescence and immunoprecipitation of the /sup 3/H-labeled proteoglycan. Furthermore, EGF stimulates (/sup 3/H)thymidine incorporation into total cell DNA. These results raise the possibility that EGF or an analogous growth factor is involved in regulation of neural crest cell morphogenesis.

• Research Organization: Univ. of California, Davis
• OSTI ID: 6524195
• Journal Information: Exp. Cell Res.; (United States), Vol. 169:2
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GLUCOPROTEINS
BIOSYNTHESIS
POLYPEPTIDES
BIOCHEMISTRY
TRITIUM COMPOUNDS
ANIMAL CELLS
CELL CULTURES
CHONDROITIN
DNA
EPIDERMIS
FLUORESCENCE
GROWTH
HYALURONIC ACID
IODINE 125
SULFATES
THYMIDINE
AMINES
ANIMAL TISSUES
AZINES
BETA DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CHEMISTRY
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EPITHELIUM
HETEROCYCLIC COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LUMINESCENCE
MUCOPOLYSACCHARIDES
NUCLEI
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PEPTIDES
POLYSACCHARIDES
PROTEINS
PYRIMIDINES
RADIOISOTOPES
RIBOSIDES
SACCHARIDES
SKIN
SULFUR COMPOUNDS
SYNTHESIS
TISSUES
550301* - Cytology- Tracer Techniques