A comprehensive human linkage map with centimorgan density

Journal Article · Fri Sep 30 04:00:00 EDT 1994 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.8091227· OSTI ID:6523984

Murray, J C; Sheffield, V C; Sunden, S ^[1]; Buetow, K H; Ludwigsen, S; Scherpbier-Heddema, T; Manion, F; Quillen, J ^[2]; Weber, J L ^[3]; Duyk, G M ^[4]

---

1. Univ. of Iowa, Iowa City, IA (United States)
2. Fox Chase Cancer Center, Philadelphia, PA (United States)
3. Marshfield Medical Research Foundation, WI (United States)
4. Harvard Medical School, Boston, MA (United States); and others

In the last few years there have been rapid advances in developing genetic maps for humans, greatly enhancing our ability to localize and identify genes for inherited disorders. Through the collaborative efforts of three large groups generating microsatellite markers and the efforts of the 110 CEPH collaborators, a comprehensive human linkage map is presented here. It consists of 5840 loci, of which 970 are uniquely ordered, covering 4000 centimorgans on the sex-averaged map. Of these loci, 3617 are polymerase chain reaction-formatted short tandem repeat polymorphisms, and another 427 are genes. The map has markers at an average density of 0.7 centimorgan, providing a resource for ready transference to physical maps and achieving one of the first goals of the Human Genome Project - a comprehensive, high-density genetic map. 65 refs., 4 tabs.

• OSTI ID: 6523984
• Journal Information: Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 265:5181; ISSN SCIEAS; ISSN 0036-8075
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
GENES
GENETIC MAPPING
HUMAN POPULATIONS
MAPPING
POPULATIONS