No difference in sensitivity for occult infection between oxine and tropolone labeled In-111 leukocytes when imaged early

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6523171

Datz, F; Baker, W; Taylor, A; Alazraki, N

There is an ongoing debate whether oxine or tropolone is the best labeling agent for indium leukocytes. Recent studies have given conflicting results concerning leukocyte viability, chemotaxis, and the ability to detect abscesses early with the two materials. The authors have undertaken a long-term prospective study to see which material gives the best clinical results early, 1-4 hours following injection. To date, 55 patients have been studied. The first 35 patients' leukocytes were autologously labeled with oxine; the next 20 with tropolone. Imaging was performed 1-4 hours post injection (mean 3) and repeated at 24 hours. The diagnosis was confirmed by clinical course, x-ray studies, surgery, and necropsy studies. Oxine: 19 of 35 (54%) patient studied had a clinical site of infection. The early images had a sensitivity of only 44% (7 of 16) whereas the delayed images were 95% sensitive. Of the cases positive both early and at 24 hours, 70% had more intense uptake at 24 hours. Tropolone: 8 of 20 (40%) patient studied had a clinical site of infection. The early images had a sensitivity of 50% (4 of 8) whereas the delayed images picked up all sites of infection. Thirty-three percent of the cases positive both early and at 24 hours had more intense uptake at 24 hours. There was no statistical difference in the sensitivities between oxine and tropolone labeled white cells. At present, the authors find no difference in the early sensitivity at 1-4 hours between oxine and tropolone labeled leukocytes.

• Research Organization: Univ. of Utah School of Medicine, Salt Lake City, UT
• OSTI ID: 6523171
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AROMATICS
AZAARENES
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMAGES
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LEUKOCYTES
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXINE
PYRIDINES
QUINOLINES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
SCINTISCANNING
SENSITIVITY
TISSUE DISTRIBUTION