Oral ofloxacin therapy of Pseudomonas aeruginosa sepsis in mice after irradiation
- Research Institute, Bethesda, MD (USA)
Death subsequent to whole-body irradiation is associated with gram-negative bacterial sepsis. The effect of oral therapy with the new quinolone ofloxacin for orally acquired Pseudomonas aeruginosa infection was tested in B6D2F1 mice exposed to 7.0 Gy of bilateral radiation from 60Co. A dose of 10(7) organisms was given orally 2 days after irradiation, and therapy was started 1 day later. Only 4 of 20 untreated mice (20%) survived for at least 30 days compared with 19 of 20 mice (95%) treated with ofloxacin (P less than 0.005). P. aeruginosa was isolated from the livers of 21 to 28 untreated mice (75%), compared with only 2 of 30 treated mice (P less than 0.005). Ofloxacin reduced colonization of the ileum by P. aeruginosa; 24 of 28 untreated mice (86%) harbored the organisms, compared with only 5 of 30 (17%) with ofloxacin (P less than 0.005). This experiment was replicated twice, and similar results were obtained. These data illustrate the efficacy of the quinolone ofloxacin for oral therapy of orally acquired P. aeruginosa infection in irradiated hosts.
- OSTI ID:
- 6523160
- Journal Information:
- Antimicrobial Agents and Chemotherapy; (USA), Vol. 34:7; ISSN 0066-4804
- Country of Publication:
- United States
- Language:
- English
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BACTERIAL DISEASES
CHEMOTHERAPY
PSEUDOMONAS
INFECTIVITY
COBALT 60
MICE
ORAL ADMINISTRATION
SMALL INTESTINE
SURVIVAL TIME
WHOLE-BODY IRRADIATION
ANIMALS
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
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DIGESTIVE SYSTEM
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EXTERNAL IRRADIATION
GASTROINTESTINAL TRACT
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTESTINES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICROORGANISMS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
RODENTS
THERAPY
VERTEBRATES
YEARS LIVING RADIOISOT
560152* - Radiation Effects on Animals- Animals