Combined therapy of septicemia with ofloxacin and/or synthetic trehalose dicorynomycolate (S-TDCM) in irradiated and wounded mice (kombinierte therapie der septikaemie mit ofloxacin und/oder synthetischem trehalose-dicorynomycolat (s-tdcm) bei bestrahlten und verwundeten maeusen)
Following lethal irradiation, mice usually succumb to sepsis as a result of translocation of intestinal bacteria and impairment of the host defense system. Additional trauma in these immunocompromised mice further increases susceptibility to bacterial infection from either endogenous or exogenous origin. Treatment with ofloxacin or synthetic trehalose dicorynemycolate (S-TDCM) was evaluated in mice, which were lethally irradiated and wounded, and which died with sepsis within six days. Wounding was performed on C3H/HeN mice anesthetized by inhalation of methoxyfurane. Dorsal skin and muscle equal to 30% total body surface was removed 1 h after 8.0 Gy gamma radiation. S-TDCM, which augments nonspecific resistance to infection in irradiated mice, was given once i.p. immediately after wounding. Oxfloxacin was injected s.c. daily from day 0 to day 10. Staphylococcus aureus, Streptococcus faecium, and Escherichia coli were isolated from both the livers and wound sites of moribund, untreated mice 4 and 5 days postirradiation.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (United States)
- OSTI ID:
- 5448508
- Report Number(s):
- AD-A-235385/2/XAB; AFRRI-SR-91-14
- Country of Publication:
- United States
- Language:
- English
Similar Records
Treatment of mice with sepsis following irradiation and trauma with antibiotics and synthetic trehalose dicorynomycolate (S-TDCM). (Reannouncement with new availability information)
AFRRI reports, second quarter, April-June 1991. Technical report
Related Subjects
BACTERIAL DISEASES
CHEMOTHERAPY
RETICULOENDOTHELIAL SYSTEM
BIOLOGICAL RADIATION EFFECTS
ESCHERICHIA COLI
GAMMA RADIATION
INFECTIOUS DISEASES
LETHAL IRRADIATION
LIVER
MICE
SEPTICEMIA
STAPHYLOCOCCUS
STREPTOCOCCUS
WOUNDS
ANIMAL TISSUES
ANIMALS
BACTERIA
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
GLANDS
INJURIES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICROORGANISMS
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
THERAPY
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals