Combined therapy of septicemia with ofloxacin and/or synthetic trehalose dicorynomycolate (S-TDCM) in irradiated and wounded mice (kombinierte therapie der septikaemie mit ofloxacin und/oder synthetischem trehalose-dicorynomycolat (s-tdcm) bei bestrahlten und verwundeten maeusen)
Technical Report
·
OSTI ID:5448508
Following lethal irradiation, mice usually succumb to sepsis as a result of translocation of intestinal bacteria and impairment of the host defense system. Additional trauma in these immunocompromised mice further increases susceptibility to bacterial infection from either endogenous or exogenous origin. Treatment with ofloxacin or synthetic trehalose dicorynemycolate (S-TDCM) was evaluated in mice, which were lethally irradiated and wounded, and which died with sepsis within six days. Wounding was performed on C3H/HeN mice anesthetized by inhalation of methoxyfurane. Dorsal skin and muscle equal to 30% total body surface was removed 1 h after 8.0 Gy gamma radiation. S-TDCM, which augments nonspecific resistance to infection in irradiated mice, was given once i.p. immediately after wounding. Oxfloxacin was injected s.c. daily from day 0 to day 10. Staphylococcus aureus, Streptococcus faecium, and Escherichia coli were isolated from both the livers and wound sites of moribund, untreated mice 4 and 5 days postirradiation.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (United States)
- OSTI ID:
- 5448508
- Report Number(s):
- AD-A-235385/2/XAB; AFRRI-SR--91-14
- Country of Publication:
- United States
- Language:
- English
Similar Records
Treatment of mice with sepsis following irradiation and trauma with antibiotics and synthetic trehalose dicorynomycolate (S-TDCM)
Treatment of mice with sepsis following irradiation and trauma with antibiotics and synthetic trehalose dicorynomycolate (S-TDCM). (Reannouncement with new availability information)
Therapy of infections in mice irradiated in mixed neutron/photon fields and inflicted with wound trauma: A review of current work. (Reannouncement with new availability information)
Journal Article
·
Thu Feb 28 23:00:00 EST 1991
· Journal of Trauma; (USA)
·
OSTI ID:5838540
Treatment of mice with sepsis following irradiation and trauma with antibiotics and synthetic trehalose dicorynomycolate (S-TDCM). (Reannouncement with new availability information)
Technical Report
·
Mon Dec 30 23:00:00 EST 1991
·
OSTI ID:91419
Therapy of infections in mice irradiated in mixed neutron/photon fields and inflicted with wound trauma: A review of current work. (Reannouncement with new availability information)
Technical Report
·
Mon Dec 30 23:00:00 EST 1991
·
OSTI ID:166853
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BACTERIA
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CHEMOTHERAPY
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
ESCHERICHIA COLI
GAMMA RADIATION
GLANDS
INFECTIOUS DISEASES
INJURIES
IONIZING RADIATIONS
IRRADIATION
LETHAL IRRADIATION
LIVER
MAMMALS
MICE
MICROORGANISMS
ORGANS
RADIATION EFFECTS
RADIATIONS
RETICULOENDOTHELIAL SYSTEM
RODENTS
SEPTICEMIA
STAPHYLOCOCCUS
STREPTOCOCCUS
THERAPY
TISSUES
VERTEBRATES
WOUNDS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BACTERIA
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CHEMOTHERAPY
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
ESCHERICHIA COLI
GAMMA RADIATION
GLANDS
INFECTIOUS DISEASES
INJURIES
IONIZING RADIATIONS
IRRADIATION
LETHAL IRRADIATION
LIVER
MAMMALS
MICE
MICROORGANISMS
ORGANS
RADIATION EFFECTS
RADIATIONS
RETICULOENDOTHELIAL SYSTEM
RODENTS
SEPTICEMIA
STAPHYLOCOCCUS
STREPTOCOCCUS
THERAPY
TISSUES
VERTEBRATES
WOUNDS