Dual isotope technique for in vivo quantitative assessment of intra-arterial(IA) drug delivery to hepatic metastases

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6523118

Line, B R; Harper, G; Armstrong, M; Ruckdeschel, J

Qualitative Tc-99m macro-aggregated albumin (MAA) scans can evaluate both IA catheter placement and regional hepatic perfusion. The authors report a new, dual isotope technique for the quantitative assessment of IA drug delivery to hepatic metastases (mets). Four patients (pts) with colon cancer metastatic to liver were treated for two week cycles with continuous IA 5-fluoro-2'-deoxyuridine (FUDR) infusion via an implantable pump (INFUSAID) at a dose of 0.1 to 0.3 mg/kg/d. At four week intervals each patient had quantitative hepatic imaging studies with Tc-99m SC to estimate met volume followed immediately by Tc-99m MAA through the pump to map drug distribution. MAA was distinguished from SC by computer subtraction and a distribution index (DI) expressed as the ratio of MAA in tumor vs normal tissues was determined. The lesion volume and DI were used to calculate the amount of FUDR delivered to tumor during treatment. Marked variability was found in the DI and chemotherapy delivered to tumor tissue between and within different pts. Pretreatment DIs were estimated to be 54%, 20%, 15%, and 1%. One pt demonstrated a drop in relative blood flow from a pretreatment DI of 54% to 49% at 4 weeks, and 37% at 8 weeks. The pt with the least DI (1.1%-5.0%) had the largest tumor burden (900 gm) and the smallest FUDR tumor delivery (0.2-1.1 ng/gm/min). The pt with the smallest tumor burden (80 gm) had the greatest FUDR delivery (14.8-22.1 ng/gm/min). This imaging technique provides quantitative estimates of tumor size and relative perfusion which can evaluate drug delivery to tumor and refine the assessment of both antitumor drug activity and toxicity of IA hepatic chemotherapy.

• Research Organization: Albany Medical Center, Albany, NY
• OSTI ID: 6523118
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CAT SCANNING
CHEMOTHERAPY
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DOSIMETRY
DRUGS
GLANDS
HOURS LIVING RADIOISOTOPES
IN VIVO
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIVER
MONITORING
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIATION DOSE DISTRIBUTIONS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
SCINTISCANNING
SPATIAL DOSE DISTRIBUTIONS
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
TISSUE DISTRIBUTION
TOMOGRAPHY
TOXICITY
TRACER TECHNIQUES
UPTAKE
YEARS LIVING RADIOISOTOPES