Effects of recombinant human granulocyte colony-stimulating factor on the hematologic recovery and survival of irradiated mice

Journal Article · Wed Aug 01 00:00:00 EDT 1990 · Blood (Journal of Hematology); (USA)

OSTI ID:6523048

Tanikawa, S; Nose, M; Aoki, Y; Tsuneoka, K; Shikita, M; Nara, N ^[1]

---

1. National Institute of Radiological Sciences, Chiba (Japan)

We studied the effects of intraperitoneal injections of recombinant human granulocyte colony-stimulating factor (rhG-CSF) according to various administration schedules on the recovery of spleen colony-forming units (CFU-S) and peripheral blood counts, and on the survival of irradiated mice. The sooner and more frequently the mice were injected with rhG-CSF after irradiation, the more enhanced the recovery of CFU-S in bone marrow was obtained on day 7. Twice-daily injections of rhG-CSF from day 0 to day 2 significantly enhanced the recovery of platelets and hematocrit, but two injections of rhG-CSF on only day 0 did not. Twice-daily injections of rhG-CSF from day 0 to day 6 enhanced the recovery of platelets more effectively than twice-daily injections of rhG-CSF from day 1 to day 7, and increased the survival of irradiated mice more effectively than any other examined administration schedules. Twice-daily injections of rhG-CSF from day 0 to day 6 were significantly effective in enhancing the survival of mice irradiated with 8.5-, 9.0-, and 9.5-Gy x-rays, although not effective after irradiation of 10.5-Gy x-rays.

• OSTI ID: 6523048
• Journal Information: Blood (Journal of Hematology); (USA), Vol. 76:3; ISSN 0006-4971
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
GROWTH FACTORS
RADIOSENSITIVITY EFFECTS
BIOLOGICAL RECOVERY
BLOOD COUNT
BONE MARROW
COLONY FORMATION
DOSE-RESPONSE RELATIONSHIPS
INTRAPERITONEAL INJECTION
MICE
PROTEINS
SPLEEN
SURVIVAL CURVES
X RADIATION
ANIMAL TISSUES
ANIMALS
BODY
ELECTROMAGNETIC RADIATION
HEMATOPOIETIC SYSTEM
INJECTION
INTAKE
IONIZING RADIATIONS
MAMMALS
MITOGENS
ORGANIC COMPOUNDS
ORGANS
RADIATIONS
RECOVERY
RODENTS
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals