Effects of recombinant human granulocyte colony-stimulating factor on the hematologic recovery and survival of irradiated mice

Journal Article · Wed Aug 01 00:00:00 EDT 1990 · Blood (Journal of Hematology); (USA)

OSTI ID:6523048

Tanikawa, S; Nose, M; Aoki, Y; Tsuneoka, K; Shikita, M; Nara, N ^[1]

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1. National Institute of Radiological Sciences, Chiba (Japan)

We studied the effects of intraperitoneal injections of recombinant human granulocyte colony-stimulating factor (rhG-CSF) according to various administration schedules on the recovery of spleen colony-forming units (CFU-S) and peripheral blood counts, and on the survival of irradiated mice. The sooner and more frequently the mice were injected with rhG-CSF after irradiation, the more enhanced the recovery of CFU-S in bone marrow was obtained on day 7. Twice-daily injections of rhG-CSF from day 0 to day 2 significantly enhanced the recovery of platelets and hematocrit, but two injections of rhG-CSF on only day 0 did not. Twice-daily injections of rhG-CSF from day 0 to day 6 enhanced the recovery of platelets more effectively than twice-daily injections of rhG-CSF from day 1 to day 7, and increased the survival of irradiated mice more effectively than any other examined administration schedules. Twice-daily injections of rhG-CSF from day 0 to day 6 were significantly effective in enhancing the survival of mice irradiated with 8.5-, 9.0-, and 9.5-Gy x-rays, although not effective after irradiation of 10.5-Gy x-rays.

• OSTI ID: 6523048
• Journal Information: Blood (Journal of Hematology); (USA), Journal Name: Blood (Journal of Hematology); (USA) Vol. 76:3; ISSN BLOOA; ISSN 0006-4971
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL RECOVERY
BLOOD COUNT
BODY
BONE MARROW
COLONY FORMATION
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
GROWTH FACTORS
HEMATOPOIETIC SYSTEM
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
IONIZING RADIATIONS
MAMMALS
MICE
MITOGENS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RECOVERY
RODENTS
SPLEEN
SURVIVAL CURVES
TISSUES
VERTEBRATES
X RADIATION