2,3,7,8-tetrachlorodibenzo-p-dioxin pretreatment of female mice altered tissue distribution but not hepatic metabolism of a subsequent dose

Technical Report · Mon Jan 01 04:00:00 EST 1990

OSTI ID:6521208

Curtis, L R; Kerkvliet, N I; Baecher-Steppan, L; Carpenter, H M

Concern over environmental contamination with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) stimulated research of its toxic actions and underlying molecular events. Various epithelia, epithelial-derived tissues such as liver, and the immune system were identified as major target tissues. A toxic mechanism based upon interaction of TCDD with the Ah receptor and subsequent expression of a pleiotropic response provided an explanation for many reported phenomena. In light of the tissue and subcellular specificity of TCDD action, tissue distribution of a given dose likely has substantial effects on patterns of tissue damage. Further, chronic toxicity of repeated low doses may be influenced by factors which increase or decrease TCDD concentrations to which particular cell types are exposed.

• Research Organization: Oregon State Univ., Corvallis, OR (USA). Dept. of Fisheries and Wildlife
• OSTI ID: 6521208
• Report Number(s): AD-A-223537/2/XAB; CNN: AFOSR-87-0185
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
BODY
DIGESTIVE SYSTEM
DIOXIN
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
EPITHELIUM
GLANDS
HETEROCYCLIC COMPOUNDS
IMMUNITY
LIVER
METABOLISM
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
RETICULOENDOTHELIAL SYSTEM
TISSUE DISTRIBUTION
TISSUES
TOXICITY