Aspects of aluminum toxicity

Journal Article · Fri Jun 01 04:00:00 EDT 1990 · Clinics in Laboratory Medicine; (USA)

OSTI ID:6520863

Hewitt, C D; Savory, J; Wills, M R ^[1]

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1. Univ. of Virginia Health Sciences Center, Charlottesville (USA)

Aluminum is the most abundant metal in the earth's crust. The widespread occurrence of aluminum, both in the environment and in foodstuffs, makes it virtually impossible for man to avoid exposure to this metal ion. Attention was first drawn to the potential role of aluminum as a toxic metal over 50 years ago, but was dismissed as a toxic agent as recently as 15 years ago. The accumulation of aluminum, in some patients with chronic renal failure, is associated with the development of toxic phenomena; dialysis encephalopathy, osteomalacic dialysis osteodystrophy, and an anemia. Aluminum accumulation also occurs in patients who are not on dialysis, predominantly infants and children with immature or impaired renal function. Aluminum has also been implicated as a toxic agent in the etiology of Alzheimer's disease, Guamiam amyotrophic lateral sclerosis, and parkinsonism-dementia. 119 references.

• OSTI ID: 6520863
• Journal Information: Clinics in Laboratory Medicine; (USA), Journal Name: Clinics in Laboratory Medicine; (USA) Vol. 10:2; ISSN 0272-2712; ISSN CLMED
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALUMINIUM
ANIMALS
BIOLOGICAL ACCUMULATION
BODY
DISEASES
DOCUMENT TYPES
ELEMENTS
ENVIRONMENTAL EXPOSURE
KIDNEYS
MAMMALS
MAN
METALS
ORGANS
PRIMATES
REVIEWS
TOXICITY
UROGENITAL SYSTEM DISEASES
VERTEBRATES