Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease
Journal Article
·
· Science (Washington, D.C.); (United States)
Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the ..beta.. peptide of brain amyloid from Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids, including the known amino acid sequence of this polypeptide. The 3.5-kilobase messenger RNA was detected in mammalian brains and human thymus. The gene is highly conserved in evolution and has been mapped to human chromosome 21.
- Research Organization:
- National Institutes of Health, Bethesda, MD
- OSTI ID:
- 6518558
- Journal Information:
- Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 235; ISSN SCIEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides
Molecular cloning and chromosomal localization of the nucleic acid sequences encoding the cerebrovascular and plaque amyloid peptide
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer's disease: Identification as the microtubule-associated protein tau
Journal Article
·
Mon Jun 01 00:00:00 EDT 1987
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:5356740
Molecular cloning and chromosomal localization of the nucleic acid sequences encoding the cerebrovascular and plaque amyloid peptide
Conference
·
Fri May 01 00:00:00 EDT 1987
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
·
OSTI ID:6157596
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer's disease: Identification as the microtubule-associated protein tau
Journal Article
·
Wed Jun 01 00:00:00 EDT 1988
· Proceedings of the National Academy of Sciences of the United States of America; (USA)
·
OSTI ID:5565392
Related Subjects
550200 -- Biochemistry
550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
AMINO ACID SEQUENCE
ANIMALS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHROMOSOMES
CLONING
DATA
DISEASES
DNA SEQUENCING
DNA-CLONING
EXPERIMENTAL DATA
GENES
GENETIC MAPPING
INFORMATION
LYMPHATIC SYSTEM
MAMMALS
MAN
MAPPING
MESSENGER-RNA
MOLECULAR STRUCTURE
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEIC ACIDS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PEPTIDES
POLYPEPTIDES
PRIMATES
PROTEINS
RNA
STRUCTURAL CHEMICAL ANALYSIS
THYMUS
VERTEBRATES
550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
AMINO ACID SEQUENCE
ANIMALS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHROMOSOMES
CLONING
DATA
DISEASES
DNA SEQUENCING
DNA-CLONING
EXPERIMENTAL DATA
GENES
GENETIC MAPPING
INFORMATION
LYMPHATIC SYSTEM
MAMMALS
MAN
MAPPING
MESSENGER-RNA
MOLECULAR STRUCTURE
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEIC ACIDS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PEPTIDES
POLYPEPTIDES
PRIMATES
PROTEINS
RNA
STRUCTURAL CHEMICAL ANALYSIS
THYMUS
VERTEBRATES