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Effects of an ambient level of ozone on primate nasal epithelial mucosubstances. Quantitative histochemistry

Journal Article · · Am. J. Pathol.; (United States)
OSTI ID:6516648
; ; ; ;
Despite the absorption of inhaled oxidant gases by the nasal cavity, little effort has been made to characterize the effects of these oxidants on the nasal mucosa. This study defines the effects of ambient concentrations of ozone on the character and amount of mucosubstances in epithelium of nasal mucosa. Bonnet monkeys were exposed to 0.00 or 0.15 ppm O/sub 3/ (8 hr/day) for 6 or 90 days, anesthetized, and exsanguinated. Nasal cavities were fixed with Karnovsky's fixative, decalcified, and processed for light microscopy, and sections were stained with alcian blue (pH 2.5)/periodic acid-Schiff or high iron diamine. Volume densities of secretory material in nasal epithelium were determined with the use of a Quantimet 900 image analyzer. After 6 days' exposure there were significant increases in both acidic and neutral glycoconjugates stored in transitional and respiratory epithelium. After 90 days there was significantly less mucosubstance than at 6 days. Only in the transitional epithelium did the total and sulfated mucosubstance remain greater than that of controls. Nasopharyngeal epithelium was minimally affected after 6 days of O/sub 3/ and unchanged after 90 days. It is concluded that exposures to ambient levels of O/sub 3/ induce significant changes in the stored secretory product of nasal epithelium.
Research Organization:
Univ. of California, Davis
OSTI ID:
6516648
Journal Information:
Am. J. Pathol.; (United States), Journal Name: Am. J. Pathol.; (United States) Vol. 1; ISSN AJPAA
Country of Publication:
United States
Language:
English

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Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMAL TISSUES
ANIMALS
BODY
BODY AREAS
CARBOHYDRATES
CHEMICAL COMPOSITION
DIGESTIVE SYSTEM
EPITHELIUM
FACE
HEAD
MAMMALS
MEMBRANES
MONKEYS
MUCOUS MEMBRANES
NOSE
ORGANIC COMPOUNDS
ORGANS
OZONE
PHARYNX
POLLUTION
PRIMATES
RESPIRATORY SYSTEM
STAINS
TISSUES
TOXICITY
VERTEBRATES