Response of the macaque nasal epithelium to ambient levels of ozone. A morphologic and morphometric study of the transitional and respiratory epithelium
Journal Article
·
· Am. J. Pathol.; (United States)
OSTI ID:6321411
Although ozone (O/sub 3/)-induced bronchiolitis has been morphologically characterized, effects of O/sub 3/ on the upper respiratory tract have not been thoroughly investigated. The purpose of this study was to determine whether exposures to ambient levels of O/sub 3/ induce lesions in the nasal mucosa. Bonnet monkeys were exposed to 0.00, 0.15, or 0.30 ppm O/sub 3/ for 6 or 90 days, 8 hours/day. After exposure, nasal mucosa was processed for light and electron microscopy. Quantitative changes were evident in the nasal transitional and respiratory epithelium. At 6 or 90 days of exposure to 0.15 or 0.30 ppm O/sub 3/ lesions consisted of ciliated cell necrosis, shortened cilia, and secretory cell hyperplasia. Inflammatory cell influx was only present at 6 days of exposure. Ultrastructural changes in goblet cells were evident at 90 days. Ambient levels of O/sub 3/ can induce significant nasal epithelial lesions, which may compromise upper respiratory defense mechanisms.
- Research Organization:
- California Primate Research Center, Davis
- OSTI ID:
- 6321411
- Journal Information:
- Am. J. Pathol.; (United States), Journal Name: Am. J. Pathol.; (United States) Vol. 128:1; ISSN AJPAA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BODY
DIGESTIVE SYSTEM
EPITHELIUM
MACACUS
MAMMALS
MEMBRANES
MONKEYS
MORPHOLOGICAL CHANGES
MUCOUS MEMBRANES
NECROSIS
ORGANS
OZONE
PATHOLOGICAL CHANGES
PHARYNX
PRIMATES
RESPIRATORY SYSTEM
TIME DEPENDENCE
TISSUES
TOXICITY
ULTRASTRUCTURAL CHANGES
VERTEBRATES
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BODY
DIGESTIVE SYSTEM
EPITHELIUM
MACACUS
MAMMALS
MEMBRANES
MONKEYS
MORPHOLOGICAL CHANGES
MUCOUS MEMBRANES
NECROSIS
ORGANS
OZONE
PATHOLOGICAL CHANGES
PHARYNX
PRIMATES
RESPIRATORY SYSTEM
TIME DEPENDENCE
TISSUES
TOXICITY
ULTRASTRUCTURAL CHANGES
VERTEBRATES