Carcinogenicity of extract of airborne particles using newborn mice and comparative study of carcinogenic and mutagenic effect of the extract
Journal Article
·
· Arch. Environ. Health; (United States)
An organic extract of airborne particles collected in Tokyo and its fractions (neutral, acidic, and basic) were investigated in Ames Salmonella assays for mutagenicity and in newborn mice for carcinogenicity. Mutagenicity to TA100 and TA98 strains was detected in the whole extract, the neutral, the acidic and the basic fractions with and without metabolic activation. In the carcinogenicity test, the incidence of lung tumor was as follows: whole extract, 4/25; neutral fraction, 7/25; acidic fraction, 0/20; basic fraction, 1/11; vehicle, 2/39; and uninjected, 3/47. The neutral fraction of the extract of the airborne particles showed highly potent mutagenicity and a high incidence of lung tumors in mice.
- Research Organization:
- Tokyo Metropolitan Research Institute for Environmental Protection, Japan
- OSTI ID:
- 6515575
- Journal Information:
- Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 1; ISSN AEHLA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
ASIA
BACTERIA
BODY
CARCINOGEN SCREENING
CARCINOGENESIS
COMPARATIVE EVALUATIONS
DISEASES
JAPAN
LUNGS
MAMMALS
METABOLIC ACTIVATION
MICE
MICROORGANISMS
MUTAGEN SCREENING
NEOPLASMS
ORGANS
PARTICLE SIZE
PARTICLES
PARTICULATES
PATHOGENESIS
POLLUTION
RESPIRATORY SYSTEM
RODENTS
SALMONELLA
SCREENING
SIZE
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
ASIA
BACTERIA
BODY
CARCINOGEN SCREENING
CARCINOGENESIS
COMPARATIVE EVALUATIONS
DISEASES
JAPAN
LUNGS
MAMMALS
METABOLIC ACTIVATION
MICE
MICROORGANISMS
MUTAGEN SCREENING
NEOPLASMS
ORGANS
PARTICLE SIZE
PARTICLES
PARTICULATES
PATHOGENESIS
POLLUTION
RESPIRATORY SYSTEM
RODENTS
SALMONELLA
SCREENING
SIZE
VERTEBRATES