Calculation of 2,3,7,8-TCDD equivalent concentrations of complex environmental contaminant mixtures

Journal Article · Mon Dec 01 04:00:00 EST 1986 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.8670221· OSTI ID:6515357

Eadon, G; Kaminsky, L; Silkworth, J; Aldous, K; Hilker, D; O'Keefe, P; Smith, R; Gierthy, J; Hawley, J; Kim, N

Sufficient toxicological data are now available to permit use of conventional risk assessment techniques to estimate the hazards associated with human exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD). However, many real-world exposures involve complex mixtures of dibenzodioxins, dibenzofurans, and related compounds. Historical approaches to risk assessment on such mixtures have ranged from ignoring all compounds except 2,3,7,8-TCDD itself to assuming that all compounds have potencies equal to 2,3,7,8-TCDD. An alternative approach which uses existing literature data and analytical results to calculate the 2,3,7,8-TCDD equivalent concentration of a mixture in order to predict its biological potency relative to 2,3,7,8-TCDD itself is advanced here. Previously reported in vivo acute and subchronic studies and some recently obtained analytical chemistry data are integrated here to clarify the utility of this important approach and to assess the uncertainties associated with its use. This predictive approach, and various conceptually similar ones, have now found wide applicability to the risk assessment process associated with exposure to complex mixtures of dioxins, dibenzofurans, and related compounds.

• Research Organization: New York State Dept. of Health, Albany
• OSTI ID: 6515357
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States); ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ANIMALS
AROMATICS
BODY
CALCULATION METHODS
CHLORINATED AROMATIC HYDROCARBONS
CHRONIC EXPOSURE
DIGESTIVE SYSTEM
DIOXIN
DISPERSIONS
ESTERS
EXTRAPOLATION
GLANDS
GUINEA PIGS
HALOGENATED AROMATIC HYDROCARBONS
HAZARDS
HEALTH HAZARDS
HETEROCYCLIC COMPOUNDS
LIPIDS
LIVER
MAMMALS
MAN
MIXTURES
NUMERICAL SOLUTION
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PRIMATES
RISK ASSESSMENT
RODENTS
TRIGLYCERIDES
VERTEBRATES