A proposed protocol for clinical trials of boron neutron capture therapy in glioblastoma multiforme

Conference · Thu Dec 31 23:00:00 EST 1987

OSTI ID:6514256

Dorn, III, R V; Spickard, J H; Griebenow, M L

Neutron Capture Therapy (NCT) was suggested in theory as a treatment for malignant tumors some 50 years ago. Since then, considerable data have accumulated on the mechanisms of action and possible application of this technique. This paper outlines a protocol for a controlled study of the use of Boron Neutron Capture Therapy (BNCT) for the treatment of Glioblastoma Multiforme (GM). The protocol is one component of a comprehensive national BNCT research program at the Idaho National Engineering Laboratory (INEL) directed towards validating (or invalidating) NCT as a treatment for human malignancies.

• Research Organization: EG and G Idaho, Inc., Idaho Falls (USA); Mountain States Tumor Inst., Boise, ID (USA)
• DOE Contract Number: AC07-76ID01570
• OSTI ID: 6514256
• Report Number(s): EGG-M-88103; CONF-8802102-4; ON: DE89005274
• Country of Publication: United States
• Language: English

Related Subjects

560161* -- Radionuclide Effects
Kinetics
& Toxicology-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BODY
BORON COMPOUNDS
BRAIN
CENTRAL NERVOUS SYSTEM
DISEASES
DOSE-RESPONSE RELATIONSHIPS
MEDICINE
MORTALITY
NEOPLASMS
NERVOUS SYSTEM
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NUCLEAR MEDICINE
ORGANS
PLANNING
RADIOLOGY
RADIOTHERAPY
STANDARDS
SURVIVAL TIME
TESTING
THERAPY