A proposed protocol for clinical trials of boron neutron capture therapy in glioblastoma multiforme

Conference · Thu Dec 31 23:00:00 EST 1987

OSTI ID:6404786

Dorn, III, R V; Spickard, J H; Griebenow, M L

Neutron capture therapy (NCT) was suggested in theory as a treatment for malignant tumors some 50 years ago. Since then considerable data have accumulated on the mechanisms of action and possible application of this technique. A comprehensive national boron neutron capture therapy (BNCT) research program at the Idaho National Engineering Laboratory (INEL) has been established directed toward further investigating this theory and toward validating (or invalidating) NCT as a treatment for human malignancy. As one component of this research program, a proposed protocol has been developed for a controlled study of the use of BNCT for the treatment of Glioblastoma Multiforme (GM). 1 fig.

• Research Organization: EG and G Idaho, Inc., Idaho Falls (USA)
• DOE Contract Number: AC07-76ID01570
• OSTI ID: 6404786
• Report Number(s): EGG-M-88040; CONF-8805150-9; ON: DE89005173
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BEAMS
BIOLOGICAL EFFECTS
BLOOD-BRAIN BARRIER
BODY
BORON COMPOUNDS
BRAIN
CENTRAL NERVOUS SYSTEM
CONTAMINATION
DISEASES
DOSE-RESPONSE RELATIONSHIPS
GLIOMAS
IONIZING RADIATIONS
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NEUTRON BEAMS
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEON BEAMS
ORGANS
PARTICLE BEAMS
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
SURVIVAL TIME
THERAPEUTIC USES
THERAPY
USES