Proton-nuclear magnetic resonance relaxation times in brain edema
- Univ. of Groningen (Netherland)
Proton relaxation times of protein solutions, bovine brain, and edematous feline brain tissue were studied as a function of water concentration, protein concentration, and temperature. In accordance with the fast proton exchange model for relaxation, a linear relation could be established between R1 and the inverse of the weight fraction of tissue water. This relation also applied to R2 of gray matter and of protein solutions. No straightforward relation with water content was found for R2 of white matter. Temperature-dependent studies indicated that in this case, the slow exchange model for relaxation had to be applied. The effect of macromolecules in physiological relevant concentrations on the total relaxation behavior of edematous tissue was weak. Total water content changes predominantly affected the relaxation rates. The linear relation may have high clinical potential for assessment of the status of cerebral edema on the basis of T1 and T2 readings from MR images.
- OSTI ID:
- 6511077
- Journal Information:
- Advances in Neurology; (USA), Vol. 52; ISSN 0091-3952
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BRAIN
NMR IMAGING
NERVOUS SYSTEM DISEASES
DIAGNOSIS
CATS
CATTLE
EDEMA
NUCLEAR MAGNETIC RESONANCE
PROTONS
TEMPERATURE DEPENDENCE
ANIMALS
BARYONS
BODY
CENTRAL NERVOUS SYSTEM
DIAGNOSTIC TECHNIQUES
DISEASES
DOMESTIC ANIMALS
ELEMENTARY PARTICLES
FERMIONS
HADRONS
MAGNETIC RESONANCE
MAMMALS
NERVOUS SYSTEM
NUCLEONS
ORGANS
PATHOLOGICAL CHANGES
RESONANCE
RUMINANTS
SYMPTOMS
VERTEBRATES
550600* - Medicine