Immune activation and autoantibodies in humans with long-term inhalation exposure to formaldehyde

Journal Article · Sun Jul 01 04:00:00 EDT 1990 · Archives of Environmental Health; (USA)

DOI:https://doi.org/10.1080/00039896.1990.9940805· OSTI ID:6508282

Thrasher, J D; Broughton, A; Madison, R ^[1]

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1. Thrasher Associates, Northridge, CA (USA)

Four groups of patients with long-term inhalation exposure to formaldehyde (HCHO) were compared with controls who had short-term periodic exposure to HCHO. The following were determined for all groups: total white cell, lymphocyte, and T cell counts; T helper/suppressor ratios; total Ta1+, IL2+, and B cell counts; antibodies to formaldehyde-human serum albumin (HCHO-HSA) conjugate and autoantibodies. When compared with the controls, the patients had significantly higher antibody titers to HCHO-HSA. In addition, significant increases in Ta1+, IL2+, and B cells and autoantibodies were observed. Immune activation, autoantibodies, and anti-HCHO-HSA antibodies are associated with long-term formaldehyde inhalation.

• OSTI ID: 6508282
• Journal Information: Archives of Environmental Health; (USA), Journal Name: Archives of Environmental Health; (USA) Vol. 45:4; ISSN 0003-9896; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ALBUMINS
ALDEHYDES
ANIMAL CELLS
ANIMALS
ANTIBODIES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL PROLIFERATION
CHRONIC EXPOSURE
CONNECTIVE TISSUE CELLS
FORMALDEHYDE
HAZARDS
HEALTH HAZARDS
INHALATION
INTAKE
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
ORGANIC COMPOUNDS
PATIENTS
POLLUTION
PRIMATES
PROTEINS
SOMATIC CELLS
VERTEBRATES