Tumor neutralization, immunotherapy, and chemoimmunotherapy of a friend leukemia with cells secondarily sensitized in vitro. II. Comparison of cells cultured with and without tumor to noncultured immune cells. [X radiation]
Journal Article
·
· J. Immunol.; (United States)
OSTI ID:6504131
The aim of this study was to determine if cells primed in vivo could be rendered more effective in killing tumor by secondary sensitization in vitro. C57BL/6 mice were primed with a viable antigenic syngeneic Friend leukemia (FBL-3). The immune spleen cells secondarily sensitized by 5-day culture with irradiated FBL-3 (CiFx) became significantly more effective than fresh noncultured immune cells (Ci) in in vitro cytotoxicity, tumor neutralization (Winn assay), and immunotherapy of an early leukemia. However, in chemoimmunotherapy of advanced leukemia, CiFx were no more effective than Ci. Moreover, Ci cultured with irradiated C57BL/6 spleen cells (CiCx), i.e., without secondary sensitization in vitro, became markedly less effective than noncultured Ci. C57BL/6 mice inoculated with 5 x 10/sup 6/ FBL-3 on day 0 received on day 5 cyclophosphamide (CY) plus Ci, CiFx, or CiCx. CY alone doubled the median survival time (MST) to day 26.
- Research Organization:
- Univ. of Washington, Seattle
- OSTI ID:
- 6504131
- Journal Information:
- J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 121:6; ISSN JOIMA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMAL CELLS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
CHEMOTHERAPY
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
ENDOXAN
HEMIC DISEASES
IMMUNE REACTIONS
IONIZING RADIATIONS
LEUKEMIA
NEOPLASMS
RADIATION EFFECTS
RADIATIONS
SOMATIC CELLS
SPLEEN CELLS
THERAPY
TUMOR CELLS
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMAL CELLS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
CHEMOTHERAPY
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
ENDOXAN
HEMIC DISEASES
IMMUNE REACTIONS
IONIZING RADIATIONS
LEUKEMIA
NEOPLASMS
RADIATION EFFECTS
RADIATIONS
SOMATIC CELLS
SPLEEN CELLS
THERAPY
TUMOR CELLS
X RADIATION