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Effects of sulfate aerosols upon cardiopulmonary function in squirrel monkeys (final report). (Second year final report: effects of nitrate and /or sulfate aerosols upon cardiopulmonary function)

Technical Report ·
OSTI ID:6503156
; ; ;

Squirrel monkeys were exposed to nominal concentrations of 2.5 mg/cu m of the following generated aerosols: zinc ammonium sulfate at both low (40%) and high (85%) nominal relative humidities, histamine diphosphate at low relative humidity, and ammonium bisulfate at low relative humidity. There were few statistically significant changes in oscillatory resistance, however, several trends toward increased resistance were present. Additional studies were performed using two different aerosol nebulizers to produce histamine diphosphate particles in two distinct size distributions, an order of magnitude different in size. These results, supported by data collected during sulfur dioxide exposures of squirrel monkeys, are used to discuss the suitability of Saimiri sciureus as a sensitive indicator species and oscillatory resistance as a valuable measurement of proximal airway changes. Development of the esophageal balloon technique as a means of measuring compliance and resistance in the unanesthetized squirrel monkey is discussed.

Research Organization:
Rancho Los Amigos Hospital, Inc., Downey, CA (USA). Professional Staff Association
OSTI ID:
6503156
Report Number(s):
PB-279393
Country of Publication:
United States
Language:
English

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Related Subjects

551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL GENERATORS
AEROSOLS
AMINES
AMMONIUM COMPOUNDS
AMMONIUM SULFATES
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
CARDIOVASCULAR SYSTEM
CHALCOGENIDES
COLLOIDS
DISEASES
DISPERSIONS
HETEROCYCLIC COMPOUNDS
HISTAMINE
HUMIDITY
IMIDAZOLES
INHALATION
INTAKE
MAMMALS
MONKEYS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PARTICLE SIZE
PATHOLOGICAL CHANGES
PHOSPHATES
PHOSPHORUS COMPOUNDS
PRIMATES
RESPIRATORY SYSTEM
SIZE
SOLS
SULFATES
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
TOXICITY
VERTEBRATES
ZINC COMPOUNDS
ZINC SULFATES