Absorption and disposition of /sup 203/Hg in the pregnant and nonpregnant hamster following oral administration of (/sup 203/Hg)methylmercuric chloride
Journal Article
·
· Environ. Res.; (United States)
OSTI ID:6500950
- National Center for Toxicological Research, Jefferson AR
The absorption and disposition of /sup 203/Hg was determined in pregnant and nonpregnant golden hamsters by means of ..gamma.. scintillation spectroscopy. The animals were given 5 ..mu..Ci(/sup 203/Hg)methylmercuric chloride orally on gestation Day 9. Urine and feces were collected until Day 15, when the animals were sacrificed. Adult and fetal tissues were analyzed for /sup 203/Hg concentrations. At 12 h postintubation, pregnant hamsters absorbed more of the administered dose and eliminated less methylmercury in the feces than nonpregnant animals. Beyond 12 h postintubation, the absorption and elimination patterns were similar in both groups. Comparison of organs from pregnant and nonpregnant animals revealed greater methylmercury concentrations in the cerebella, pons-medullas, and spleens of pregnant females. The fetal head was found to contain significantly more methylmercury than the fetal body.
- OSTI ID:
- 6500950
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 24:1; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560171* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBELLUM
CHLORIDES
CHLORINE COMPOUNDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
EVEN-ODD NUCLEI
FECES
FETUSES
HALIDES
HALOGEN COMPOUNDS
HAMSTERS
HEAVY NUCLEI
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
MERCURY 203
MERCURY CHLORIDES
MERCURY COMPOUNDS
MERCURY HALIDES
MERCURY ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORAL ADMINISTRATION
ORGANS
PREGNANCY
QUANTITY RATIO
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RODENTS
SCINTISCANNING
SPLEEN
TISSUE DISTRIBUTION
UPTAKE
URINE
VERTEBRATES
WASTES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBELLUM
CHLORIDES
CHLORINE COMPOUNDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
EVEN-ODD NUCLEI
FECES
FETUSES
HALIDES
HALOGEN COMPOUNDS
HAMSTERS
HEAVY NUCLEI
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
MERCURY 203
MERCURY CHLORIDES
MERCURY COMPOUNDS
MERCURY HALIDES
MERCURY ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORAL ADMINISTRATION
ORGANS
PREGNANCY
QUANTITY RATIO
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RODENTS
SCINTISCANNING
SPLEEN
TISSUE DISTRIBUTION
UPTAKE
URINE
VERTEBRATES
WASTES