Effect of vitamin B/sub 6/ on the neurotoxicity and pharmacology of desmethylmisonidazole and misonidazole: clinical and laboratory studies
Conference
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:6499997
The clinical usefulness of misonidazole (MISO) and desmethylmisonidazole (DMM) is severely limited by neurotoxicity. Based on theoretical considerations and on laboratory data suggesting that pyridoxine (PN) decreased MISO toxicity in mice. The authors attempted to ameliorate the clinical neuropathy of DMM using oral PN. Pharmacokinetic analysis suggested interaction of PN and DMM but no protection against neuropathy was observed. Serial experiments with C3H and BALB/c mice were done using various forms of vitamin B/sub 6/ (PN, pyridoxal, pyridoxal phosphate) administered orally and i.p. No consistent protection was observed. Dexamethasone did not alter MISO toxicity in mice, contrary to the clinical findings. They conclude that vitamin B/sub 6/ is not useful in preventing clinical neurotoxicity of MISO or DMM.
- Research Organization:
- Stanford Univ. Medical Center, CA
- OSTI ID:
- 6499997
- Conference Information:
- Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 10:8
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550500 -- Metabolism
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ANIMALS
ANTINEOPLASTIC DRUGS
AZINES
AZOLES
BIOLOGICAL EFFECTS
CONFIGURATION INTERACTION
CORTICOSTEROIDS
DEXAMETHASONE
DISEASES
DRUGS
GLUCOCORTICOIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
IMIDAZOLES
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
KETONES
MAMMALS
MICE
MISONIDAZOLE
NERVOUS SYSTEM DISEASES
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHARMACOLOGY
PREGNANES
PYRIDINES
PYRIDOXINE
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RODENTS
STEROID HORMONES
STEROIDS
VERTEBRATES
VITAMIN B GROUP
VITAMINS
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ANIMALS
ANTINEOPLASTIC DRUGS
AZINES
AZOLES
BIOLOGICAL EFFECTS
CONFIGURATION INTERACTION
CORTICOSTEROIDS
DEXAMETHASONE
DISEASES
DRUGS
GLUCOCORTICOIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
IMIDAZOLES
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
KETONES
MAMMALS
MICE
MISONIDAZOLE
NERVOUS SYSTEM DISEASES
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHARMACOLOGY
PREGNANES
PYRIDINES
PYRIDOXINE
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RODENTS
STEROID HORMONES
STEROIDS
VERTEBRATES
VITAMIN B GROUP
VITAMINS