Misonidazole with dexamethasone rescue: an escalating dose toxicity study
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Neurotoxicity induced by misonidazole (MISO) and desmethylmisonidazole (DMM) has become the dose limiting factor in clinical work. In 1981, the authors reported a preliminary study suggestive that Dexamethasone (DEXA) does have a protective effect against peripheral neuropathies (PN) resulting from toxicity of misonidazole. The authors are presently investigating the use of DEXA, with escalating doses of MISO in an attempt to modify its neurotoxicity. To date, 16 patients have been registered to receive total doses of MISO given in 9 equally divided doses over 3 weeks. DEXA is given 3 days prior to the first dose and continues for the duration of therapy. All patients receive palliative radiation. No toxicity was seen at the total dose of 13.5 gm/M/sub 2/. One grade I PN occurred in the first four patients receiving 15.5 gm/M/sub 2/. Six additional patients were entered at this dose level and no further incidence of PN was observed.
- Research Organization:
- Cross Cancer Inst., Edmonton, Alberta
- OSTI ID:
- 6166515
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 10:9; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Is Misonidazole neurotoxicity altered by the use of phenytoin and/or dexamethasone in RTOG 79-18 and RTOG 79-16
Conference
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Wed Aug 01 00:00:00 EDT 1984
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:6499997
High dose misonidazole with dexamethasone rescue: a possible approach to circumvent neurotoxicity
Journal Article
·
Sun Feb 28 23:00:00 EST 1982
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:6711630
Is Misonidazole neurotoxicity altered by the use of phenytoin and/or dexamethasone in RTOG 79-18 and RTOG 79-16
Journal Article
·
Sat Sep 01 00:00:00 EDT 1984
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:6166530
Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ANTINEOPLASTIC DRUGS
AZOLES
CORTICOSTEROIDS
DEXAMETHASONE
DISEASES
DRUGS
GLUCOCORTICOIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
IMIDAZOLES
INFLAMMATION
KETONES
MEDICINE
METASTASES
MISONIDAZOLE
NEOPLASMS
NERVES
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOLOGICAL CHANGES
PATIENTS
PHARMACOLOGY
PREGNANES
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
STEROID HORMONES
STEROIDS
SYMPTOMS
THERAPY
TOXICITY
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ANTINEOPLASTIC DRUGS
AZOLES
CORTICOSTEROIDS
DEXAMETHASONE
DISEASES
DRUGS
GLUCOCORTICOIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
IMIDAZOLES
INFLAMMATION
KETONES
MEDICINE
METASTASES
MISONIDAZOLE
NEOPLASMS
NERVES
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOLOGICAL CHANGES
PATIENTS
PHARMACOLOGY
PREGNANES
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
STEROID HORMONES
STEROIDS
SYMPTOMS
THERAPY
TOXICITY