Scintigraphy for pulmonary capillary protein leak. Final report, 1 October 1981-30 September 1985

Technical Report · Sun Jun 01 00:00:00 EDT 1986

OSTI ID:6498921

Sugerman, H J; Tatum, J L; Hirsch, J I; Strash, A M

Computerized scintigraphy, employing the gamma camera, has been used to study the dynamics of the pulmonary capillary membrane leak of 99m-technetium-tagged human serum albumin (Tc-HSA). In preliminary canine studies, the severity of an oleic acid-induced albumin leak was proportional to the slope of lung: heart radioactivity ratio and was more sensitive than arterial blood gases or standard chest roentgenograms. This rising ratio is called slope of injury slope index. A number of agents were studied in an attempt to prevent oleic acid-induced pulmonary microvascular injury. Following a series of five control dogs, five dogs each were studied with each of the following agents: methylprednisolone, ibuprofen, the superoxide radical scavenger, MK-44, and, in three dogs, calcium gluconate. None of these agents was able to alter the rise in lung: heart radioactivity ratio following oleic acid injury. A septic pig model was developed for study of bacterially induced ARDS. Septic-induced ARDS and multi-system organ failure are probably secondary to the systemic release of several mediators of inflammation, treatment will probably require a combination of anti-inflammatory agents. This should impact significantly on the mortality and morbidity of septic complications in traumatized combat soldiers.

• Research Organization: Medical Coll. of Virginia, Richmond (USA)
• OSTI ID: 6498921
• Report Number(s): AD-A-178067/5/XAB
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CARDIOVASCULAR SYSTEM
SEROUS MEMBRANES
PROTEINS
LEAKS
TECHNETIUM 99
SCINTISCANNING
ARTERIES
CALCIUM
CAMERAS
DOGS
DYNAMICS
HEART
INFLAMMATION
INJURIES
PHOTOGRAPHY
RADIOACTIVITY
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
ELEMENTS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MECHANICS
MEMBRANES
METALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SYMPTOMS
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
551000* - Physiological Systems