Demyelinating encephalomyelopathy associated with lead poisoning in nonhuman primates

Journal Article · Fri Sep 11 04:00:00 EDT 1970 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.169.3950.1091· OSTI ID:6498316

Sauer, R M; Zook, B C; Garner, F M

Lead poisoning was diagnosed in four primates by the finding of toxic amounts of lead in tissues. Abnormalities in the brain and spinal cord were characterized by vascular lesions and demyelination. These findings suggest a new animal model for the study of demyelination and strengthen the supposition that lead may be a factor in some idiopathic demyelinating diseases.

• Research Organization: National Zoological Park, Washington, DC
• OSTI ID: 6498316
• Journal Information: Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 169; ISSN SCIEA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL ACCUMULATION
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DISTRIBUTION
ELEMENTS
LEAD
MAMMALS
MATHEMATICAL MODELS
METALS
MONKEYS
NERVOUS SYSTEM
ORGANS
PATHOLOGICAL CHANGES
PRIMATES
SPINAL CORD
TISSUE DISTRIBUTION
TOXICITY
VERTEBRATES