Comparison of 2,2',4,4',5,5'-hexachloro(/sup 14/C)biphenyl levels in different adipose tissues of dogs and monkeys
Journal Article
·
· Fundam. Appl. Toxicol.; (United States)
The polychlorinated biphenyl isomer, 2,2',4,4',5,5'-hexachloro(/sup 14/C)biphenyl (2,4,5-HCB) was administered as a single iv dose at 0.6 mg/kg to dogs and monkeys. Adipose tissue, which included omentum, pericardial, perirenal, peritesticular, and subcutaneous fat, and blood were collected at various termination times and analyzed for total /sup 14/C and the parent hexachlorobiphenyl (HCB). Significant differences (p less than 0.0005) in the total hexachlorobiphenyl concentration as measured by total radioactivity (/sup 14/C equivalents) were noted in the various adipose tissues and in the same adipose tissues with time. Peritesticular fat was consistently lower in the concentration of /sup 14/C equivalents than the other adipose tissues, which were nearly equal. The concentrations in subcutaneous fat samples were inconsistent. Total /sup 14/C equivalent concentrations in the adipose tissues either peaked or reached a maximum at Day 1 and Day 4 for dog and monkey, respectively. However, parent HCB fat/blood ratios continually increased over the time course of the experiment, because concentrations in blood decreased more rapidly than those in adipose tissue.
- Research Organization:
- Univ. of Arizona, Tucson
- OSTI ID:
- 6498176
- Journal Information:
- Fundam. Appl. Toxicol.; (United States), Journal Name: Fundam. Appl. Toxicol.; (United States) Vol. 4:1; ISSN FAATD
- Country of Publication:
- United States
- Language:
- English
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Tue Mar 04 23:00:00 EST 1986
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
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OSTI ID:7034194
Related Subjects
550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADIPOSE TISSUE
ANIMAL TISSUES
ANIMALS
AROMATICS
BODY
CARBON 14 COMPOUNDS
CHEMICAL ANALYSIS
CHLORINATED AROMATIC HYDROCARBONS
CONNECTIVE TISSUE
DISTRIBUTION
DOGS
HALOGENATED AROMATIC HYDROCARBONS
LABELLED COMPOUNDS
MAMMALS
MONKEYS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PRIMATES
TISSUE DISTRIBUTION
TISSUES
VERTEBRATES
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADIPOSE TISSUE
ANIMAL TISSUES
ANIMALS
AROMATICS
BODY
CARBON 14 COMPOUNDS
CHEMICAL ANALYSIS
CHLORINATED AROMATIC HYDROCARBONS
CONNECTIVE TISSUE
DISTRIBUTION
DOGS
HALOGENATED AROMATIC HYDROCARBONS
LABELLED COMPOUNDS
MAMMALS
MONKEYS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PRIMATES
TISSUE DISTRIBUTION
TISSUES
VERTEBRATES