Polychlorinated biphenyl (PCB) partitioning between adipose tissue and serum
Journal Article
·
· Bull. Environ. Contam. Toxicol.; (United States)
It has been recently suggested that variabilities in the partitioning of chronically retained lipophilic xenobiotics between adipose tissue and serum may be relatable to variations in the lipid content of the serum. Here, the authors present theoretical considerations and experimental data showing that this is indeed the case for polychlorinated biphenyls (PCBs) in humans. At equilibrium, in the absence of active transport, any lipophilic substance must distribute itself among body tissues in such a way that its chemical activity and also its chemical potential are the same at all points. In order to verify the theoretical relationships, three sorts of data relating to serum PCB levels in a human population were examined.
- Research Organization:
- General Electric Research and Development Center, Schenectady, NY
- OSTI ID:
- 6498122
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 33:3; ISSN BECTA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Influence of serum cholesterol and albumin on partitioning of PCB congeners between human serum and adipose tissue
Distribution pattern and reduction of polychlorinated biphenyls (PCB) in bluefish fillets through adipose tissue removal
Polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) alter leptin signaling and lipid metabolism in differentiated 3T3-L1 adipocytes
Journal Article
·
Wed Dec 31 23:00:00 EST 1986
· Toxicol. Appl. Pharmacol.; (United States)
·
OSTI ID:6927257
Distribution pattern and reduction of polychlorinated biphenyls (PCB) in bluefish fillets through adipose tissue removal
Journal Article
·
Mon Oct 31 23:00:00 EST 1988
· Bull. Environ. Contam. Toxicol.; (United States)
·
OSTI ID:6396220
Polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) alter leptin signaling and lipid metabolism in differentiated 3T3-L1 adipocytes
Journal Article
·
Mon Sep 15 00:00:00 EDT 2014
· Toxicology and Applied Pharmacology
·
OSTI ID:22439838
Related Subjects
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADIPOSE TISSUE
ANIMAL TISSUES
AROMATICS
BIOLOGICAL ACCUMULATION
BLOOD SERUM
BODY
CHLORINATED AROMATIC HYDROCARBONS
CONNECTIVE TISSUE
FUNCTIONS
HALOGENATED AROMATIC HYDROCARBONS
MATHEMATICAL MODELS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PARTITION FUNCTIONS
PERSONNEL
THERMODYNAMIC ACTIVITY
TISSUES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADIPOSE TISSUE
ANIMAL TISSUES
AROMATICS
BIOLOGICAL ACCUMULATION
BLOOD SERUM
BODY
CHLORINATED AROMATIC HYDROCARBONS
CONNECTIVE TISSUE
FUNCTIONS
HALOGENATED AROMATIC HYDROCARBONS
MATHEMATICAL MODELS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PARTITION FUNCTIONS
PERSONNEL
THERMODYNAMIC ACTIVITY
TISSUES