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Case-control study of skin cancer in the tire and rubber manufacturing industry

Journal Article · · Am. J. Ind. Med.; (United States)
; ;
A case-control study was conducted in the tire and rubber manufacturing industry to examine the association of squamous cell carcinoma of the skin with rubber manufacturing materials presumed to be contaminated by polycyclic aromatic hydrocarbons. Sixty-five cases were compared to 254 matched controls for exposure to carbon black, extender oils, lubricating oils, rubber solvents, and rubber stock. Both magnitude and duration of exposure were compared using data from company personnel records. Rubber stock and lubricating oils were associated with skin cancer. The relative risk (RR) associated with the highest levels of rubber stock exposure was 2.2, and with the highest level of lubricating oil exposure it was 6.5. In analysis of subgroups of study members, the associations were strongest among workers who were born after 1900 (rubber stock, RR = 11.6; lubricating oil, RR = 4.5) and among workers whose skin cancer was diagnosed before the age of seventy (rubber stock, RR = 23.2; lubricating oil, RR = 28.3).
Research Organization:
Northeastern Ohio Universities College of Medicine, Rootstown
OSTI ID:
6496496
Journal Information:
Am. J. Ind. Med.; (United States), Journal Name: Am. J. Ind. Med.; (United States) Vol. 4; ISSN AJIMD
Country of Publication:
United States
Language:
English

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Related Subjects

550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BODY
CARCINOGENESIS
CARCINOMAS
DISEASES
EPIDEMIOLOGY
HAZARDS
HEALTH HAZARDS
HYDROCARBONS
INDUSTRY
NEOPLASMS
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PERSONNEL
POLYCYCLIC AROMATIC HYDROCARBONS
RISK ASSESSMENT
RUBBER INDUSTRY
SKIN