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Lung collagen in silicosis: fibrosis mechanisms. Report for 28 September 1984-31 August 1987

Technical Report ·
OSTI ID:6496460
The mechanisms involved in lung fibrosis in silicosis were investigated in rats. Studies were carried out to test whether collagen crosslinking in silicotic rat lungs differs from that found in normal lungs; to determine whether crosslinking in silicotic rat lungs differs from that in bleomycin-exposed rat lungs; to determine whether elastin crosslinking can be measured in the lungs of either normal adult rats or rats exposed to fibrogenic stimuli and if there are differences among the groups; and to develop simple screening assays of urine or blood to indicate early silicotic changes. Silicotic collagen was characterized by an increase in the ratio of the difunctional crosslinks DHLNL to HLNL, an increase in the content of the trifunctional nonreducible crosslink hydroxypyridinium and an apparent increase in lysine hydroxylatin. Long-term bleomycin experiments indicated further evidence that increased hydroxypyridinium may serve as a permanent marker of a fibrotic event that may have occurred months to years earlier. No consistent differences in crosslink excretion were noted between control and silicotic animals. The authors conclude that any small changes in crosslink excretion contributed by damaged lungs were obscured by the larger contributions of the urine crosslink pool of such tissues as bone.
Research Organization:
California Univ., Davis (USA). Dept. of Internal Medicine
OSTI ID:
6496460
Report Number(s):
PB-89-130744/XAB
Country of Publication:
United States
Language:
English

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Related Subjects

500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
552000 -- Public Health
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLEOMYCIN
BODY FLUIDS
CHEMICAL REACTIONS
CLEARANCE
COLLAGEN
CROSS-LINKING
DISEASES
DOCUMENT TYPES
DRUGS
EXCRETION
LABORATORY ANIMALS
MATERIALS
OCCUPATIONAL DISEASES
ORGANIC COMPOUNDS
PNEUMOCONIOSES
POLYMERIZATION
PROGRESS REPORT
PROTEINS
RESPIRATORY SYSTEM DISEASES
SCLEROPROTEINS
URINE
WASTES