Microcolumn high pressure liquid chromatography with a glass-frit nebulizer interface for plasma emission detection

Journal Article · Mon Apr 01 04:00:00 EST 1985 · J. Chromatogr. Sci.; (United States)

DOI:https://doi.org/10.1093/chromsci/23.4.144· OSTI ID:6481141

Ibrahim, M; Nisamaneepong, W; Caruso, J

Microcolumn high pressure liquid chromatography (micro-HPLC) is rapidly gaining recognition as a practical separation tool for organometallic compounds. The use of the inductively coupled plasma (ICP) as a detector for micro-HPLC is studied. Several miniaturized glass-frit nebulizers are investigated as interfaces between the output of the microbore column and the ICP torch. Their performance with aqueous and methanolic solutions is evaluated by direct nebulization and flow injection analysis. The most efficient of these nebulizers is used in the micro-HPLC/ICP study of some Cd, Pb, and Zn organometallic compounds. Detection limits of 1.92 ng of Pb for tetramethyllead and 5.01 ng of Pb for tetraethyllead are obtained and compared with regular HPLC/ICP of these same compounds. Approximately equivalent detection limits were obtained when using a microwave induced plasma as an alternate plasma source.

• OSTI ID: 6481141
• Journal Information: J. Chromatogr. Sci.; (United States), Journal Name: J. Chromatogr. Sci.; (United States) Vol. 4; ISSN JCHSB
• Country of Publication: United States
• Language: English

Related Subjects

440101* -- Radiation Instrumentation-- General Detectors or Monitors & Radiometric Instruments
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
AQUEOUS SOLUTIONS
CADMIUM
CHROMATOGRAPHY
DISPERSIONS
ELEMENTS
LEAD
LIQUID COLUMN CHROMATOGRAPHY
MEASURING INSTRUMENTS
METALS
MIXTURES
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
PERFORMANCE TESTING
SEPARATION PROCESSES
SOLUTIONS
SOLVENTS
SPECTROMETERS
TESTING
X-RAY SPECTROMETERS
ZINC