Specific absorbed fractions of energy from internal photon sources in brain tumor and cerebrospinal fluid

Journal Article · Wed Mar 01 00:00:00 EST 1995 · Medical Physics; (United States)

DOI:https://doi.org/10.1118/1.597448· OSTI ID:6481097

Evans, J F ^[1]; Stubbs, J B ^[2]

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1. Nuclear Engineering Program, Ohio State University, Columbus (Ohio (United States))
2. Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee 37831-0117 (United States)

Transferrin, radiolabeled with In-111, can be coinjected into glioblastoma multiforme lesions, and subsequent scintigraphic imaging can demonstrate the biokinetics of the cytotoxic transferrin. The administration of [sup 111]In transferrin into a brain tumor results in distribution of radioactivity in the brain, brain tumor, and the cerebrospinal fluid (CSF). Information about absorbed radiation doses to these regions, as well as other nearby tissues and organs, is important for evaluating radiation-related risks from this procedure. The radiation dose is usually estimated for a mathematical representation of the human body. We have included source/target regions for the eye, lens of the eye, spinal column, spinal CSF, cranial CSF, and a 100-g tumor within the brain of an adult male phantom developed by Cristy and Eckerman. The spinal column, spinal CSF, and the eyes have not been routinely included in photon transport simulations. Specific absorbed fractions (SAFs) as a function of photon energy were calculated using the ALGAMP computer code, which utilizes Monte Carlo techniques for simulating photon transport. The ALGAMP code was run three times, with the source activity distributed uniformly within the tumor, cranial CSF, and the spinal CSF volumes. These SAFs, which were generated for 12 discrete photon energies ranging from 0.01 to 4.0 MeV, were used with decay scheme data to calculate [ital S]-values needed for estimating absorbed doses. [ital S]-values for [sup 111]In are given for three source regions (brain tumor, cranial CSF, and spinal CSF) and all standard target regions/organs, the eye and lens, as well as to tissues within these source regions. [ital S]-values for the skeletal regions containing active marrow are estimated. These results are useful in evaluating the radiation doses from intracranial administration of [sup 111]In transferrin.

• DOE Contract Number: AC05-76OR00033
• OSTI ID: 6481097
• Journal Information: Medical Physics; (United States), Vol. 22:3; ISSN 0094-2405
• Country of Publication: United States
• Language: English

Related Subjects

61 RADIATION PROTECTION AND DOSIMETRY
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
NEOPLASMS
CEREBROSPINAL FLUID
INTERNAL IRRADIATION
A CODES
INDIUM
PHANTOMS
SPATIAL DOSE DISTRIBUTIONS
TRANSFERRIN
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CENTRAL NERVOUS SYSTEM
COMPUTER CODES
DISEASES
ELEMENTS
GLOBULINS
GLOBULINS-BETA
IRRADIATION
MATERIALS
METALLOPROTEINS
METALS
MOCKUP
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATION DOSE DISTRIBUTIONS
STRUCTURAL MODELS
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