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Radiostrontium clearance and bone formation in response to simulated internal screw fixation

Journal Article · · Clin. Orthop. Relat. Res.; (United States)
; ; ;
Changes in radiostrontium clearance (SrC) and bone formation (tetracycline labeling) were observed in the femurs of skeletally mature dogs following the various operative steps involved in bone screw fixation. Drilling, but not periosteal stripping, produced a small but statistically significant increase in SrC and endosteal bone formation in the distal third of the bone. Strontium clearance values equivalent to those produced by drilling alone were recorded after screw fixation at low or high torque (5 versus 20 inch pounds), as well as by the insertion of loosely fitting stainless steel implants. Bone formation (equals the percentage tetracycline-labeled trabecular bone surfaces) was increased by 30% when SrC values exceeded 3.5 ml/100 g bone/min, and the relationship was linear when SrC values ranged between 1.0 and 7.0 ml/100 g bone/min. The changes in SrC and bone formation one-week after bone screw application are primarily those associated with a response to local trauma caused by drilling.
Research Organization:
Univ. of Texas Medical Branch, Galveston
OSTI ID:
6476679
Journal Information:
Clin. Orthop. Relat. Res.; (United States), Journal Name: Clin. Orthop. Relat. Res.; (United States) Vol. 219; ISSN CORTB
Country of Publication:
United States
Language:
English

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Related Subjects

550600* -- Medicine
560162 -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ANIMAL CELLS
ANIMALS
BODY
BONE CELLS
BONE JOINTS
CLEARANCE
CONNECTIVE TISSUE CELLS
DOGS
FEMUR
IMPLANTS
ISOTOPES
MAMMALS
MEDICINE
ORGANS
RADIONUCLIDE KINETICS
SKELETON
SOMATIC CELLS
STRONTIUM ISOTOPES
SURGERY
VERTEBRATES