Regional alterations in long bone /sup 85/Sr clearance produced by internal fixation devices. Part II. Histomorphometry

Journal Article · Fri Jan 01 04:00:00 EST 1988 · J. of Orthopaedi. Trauma; (United States)

DOI:https://doi.org/10.1097/00005131-198802030-00012· OSTI ID:6325033

Simmons, D J; Daum, W J; Calhoun, J H

The effects of each of the surgical stages involved in compression plating on the development of cortical thinning and porosity were assessed in the intact midshaft, stress-shielded femoral segments of adult mongrel dogs 6 months postoperatively. The data were evaluated in terms of a postsurgical tetracycline-based measure of remodeling and terminal /sup 85/Sr clearance (SrC) values for the plated segments of bone. Drilling had no effect on any parameter. Screw application was associated with minimal cortical thinning (p less than 0.05), while plate fixation clearly promoted thinning (p less than 0.01) and porosity (p less than 0.05). The percentage of labeled osteons, a measure of remodeling activity, increased only after plate fixation (p less than 0.05), and the labeling patterns suggested that most osteons had formed during the first 4 postsurgical months. That none of these changes were correlated with the 6-month SrC values suggests that the development of plate-induced osteopenia involves disparate histomorphometric time constants, rather than lack of any association.

• Research Organization: Univ. of Texas Medical Branch, Galveston (USA)
• OSTI ID: 6325033
• Journal Information: J. of Orthopaedi. Trauma; (United States), Journal Name: J. of Orthopaedi. Trauma; (United States) Vol. 2:3; ISSN JORTE
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL STRESS
BLOOD FLOW
BODY
BONE FRACTURES
CLEARANCE
DAYS LIVING RADIOISOTOPES
DISEASES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FEMUR
HOURS LIVING RADIOISOTOPES
INJURIES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
MEDICAL SUPPLIES
NUCLEI
ORGANS
PROSTHESES
RADIOISOTOPES
SKELETAL DISEASES
SKELETON
STRONTIUM 85
STRONTIUM ISOTOPES
SURGICAL MATERIALS
TRACER TECHNIQUES
VERTEBRATES