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Kinetics of (/sup 11/C)N,N-dimethylphenylethylamine in mice and humans: potential for measurement of brain MAO-B activity

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:6476232
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Carbon-11-labeled N,N-dimethylphenylethylamine ((/sup 11/C)DMPEA) was synthesized by the reaction of N-methylphenylethylamine with (/sup 11/C)methyl iodide. This newly synthesized radiotracer was developed for the purpose of in vivo measurement of monoamine oxidase-B activity in the brain using a metabolic trapping method. Initially, biodistribution was investigated in mice. The rapid and high uptake of /sup 11/C radioactivity in the brain was observed following intravenous injection of (/sup 11/C)DMPEA, the peak of which was reached at 1 min, followed by a decrease at 1-5 min and slowly thereafter. The kinetics of (/sup 11/C)DMPEA in the human brain were determined using positron emission tomography (PET) and showed that /sup 11/C radioactivity increased gradually over 60 min following initial rapid uptake of /sup 11/C radioactivity, with basal ganglia and thalamus showing high accumulation.

Research Organization:
National Institute of Radiological Sciences, Chiba, Japan
OSTI ID:
6476232
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 6; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINE OXIDASES
AMINES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BODY
BRAIN
CARBON 11
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
CHEMICAL PREPARATION
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DRUGS
DYNAMIC FUNCTION STUDIES
EMISSION COMPUTED TOMOGRAPHY
ENZYME ACTIVITY
ENZYMES
EVEN-ODD NUCLEI
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MAN
MICE
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
RADIOISOTOPES
RADIOPHARMACEUTICALS
REACTION KINETICS
RODENTS
SYNTHESIS
TISSUE DISTRIBUTION
TOMOGRAPHY
VERTEBRATES